Director, Pharmacology

Flagship Pioneering, Inc.•Somerville, MA

8d•$180,000 - $248,000

About The Position

Cellarity is seeking a highly strategic Sr. Director, Pharmacology to connect biology, pharmacology, DMPK, and translational science across inflammation and hematology programs. Reporting to the Sr. Director of Lab Science, this role will partner closely with biology, chemistry, DMPK, toxicology, external CROs, and scientific leadership to drive programs from early discovery through candidate selection.

Requirements

PhD in biology, pharmacology, or a related scientific discipline, with 10-15+ years of relevant experience in biotech or pharmaceutical drug discovery and development.
Strong foundation in preclinical pharmacology with demonstrated experience translating biology into in vivo efficacy and PK/PD insight.
Experience connecting in vitro findings to in-vivo outcomes, including target engagement, exposure-response relationships, and translational biomarker strategy.
Exposure to DMPK and ability to partner effectively with DMPK scientists on program interpretation and advancement.
Proven track record of working across biology, chemistry, pharmacology, and external collaborators to influence drug discovery strategy.
Experience managing and interpreting outsourced pharmacology studies through CROs.
Strong scientific judgment, data integration skills, and the ability to build decision-enabling narratives from diverse datasets.
Excellent written and verbal communication skills, including the ability to influence scientific teams and leadership in a matrixed environment.
Ability to thrive in a fast-paced, highly collaborative research environment with broad program visibility.

Nice To Haves

Experience in hematology, particularly in combination with oncology.
Experience supporting inflammation or immunology programs.
Strong publication record spanning pharmacology, translational biology, medicinal chemistry, chemical biology, or drug discovery.
Experience working in smaller, cross-functional biotech environments.
Demonstrated ability to grow into broader translational leadership over time.

Responsibilities

Lead preclinical pharmacology strategy across multiple discovery programs, with a focus on translating in vitro biology and functional assay data into meaningful in vivo outcomes.
Drive PK/PD interpretation, exposure-response assessment, target coverage analysis, and translational biomarker strategy to inform program decisions.
Integrate data across biology, pharmacology, medicinal chemistry, and DMPK to build clear scientific narratives and guide candidate advancement.
Oversee outsourced pharmacology studies and manage external CRO relationships to ensure studies are scientifically rigorous, well interpreted, and aligned to program objectives.
Partner with internal scientific teams to define critical experiments, interpret data packages, and determine what additional studies are needed to advance programs with confidence.
Provide strategic input to cross-functional program discussions from early discovery through candidate selection.
Represent pharmacology at internal scientific and program meetings, communicating findings, risks, and recommendations with clarity and precision.
Contribute to the development of broader translational approaches as the organization continues to expand its preclinical pipeline.