Director of Chemistry, Small Molecule Process Development and Manufacturing

Biogen•Cambridge, MA

5d•$188,000 - $259,000•Onsite

About The Position

We are seeking a highly motivated and creative Director of Chemistry to join our Small Molecule Chemical Development team. In this role, you will lead and mentor scientific and engineering teams as you guide project progression from early-phase through late-phase drug development. You will oversee the design and refinement of robust manufacturing processes for a wide range of small molecules, supporting pre-clinical and clinical therapeutics. This role is integral to advancing our scientific endeavors, driving innovation, and enabling the successful launch of new medicines through collaborative, safe, economical, and sustainable process development.

Requirements

M.S. or PhD with 12+ years of relevant experience, including people management, in pharmaceutical or biotech settings is required
Strong background in the theory and practice of pharmaceutical process chemistry and engineering, including command of synthetic strategies, impurity controls, analytical, purification and isolation techniques, process characterization, familiarity with process safety and tech transfer protocols, and good problem-solving skills in the service of delivering non-clinical and clinical APIs and the phase appropriate knowledge packages for CMC support.
Demonstrated experience in leading project teams involved in delivery of APIs across several modalities
Ability to lead teams ethically, collaboratively, effectively, and cross-functionally
Excellent communication and interpersonal skills are required along with the desire to work in a highly collaborative team environment.

Nice To Haves

Experience in engaging with external partners and representing the organization in external facing settings.
Familiarity with regulatory requirements and CMC activities related to drug development.

Responsibilities

Lead collaborative development and manufacturing teams to design and conduct experiments to optimize and characterize the processes of Biogen assets with an emphasis on improvement in process understanding, robustness, and productivity.
Design, guide and execute experimental plans to advance the Biogen portfolio.
Responsible for leading project teams towards the implementation of safe, efficient and robust chemical processes Biogen drug candidates.
Collaborate with development and manufacturing teams to optimize and characterize the processes of Biogen assets with an emphasis on improvement in process understanding, robustness, and productivity.
Responsible for managing scientific colleagues, and mentoring, engaging, and preparing our future scientific and engineering leaders
Develop the fundamental process knowledge needed to support the transition of chemical and biochemical processes from laboratory scale to manufacturing partners.
Collaborate with our Process Engineering, Analytical Chemistry, Oligo Synthesis, Solid Form, and Separations colleagues to develop the knowledge and controls needed for the supply of clinical materials and characterization of processes to support regulatory filings.
Communicate project team research results effectively by in reports and discussions in team meetings, including engagement in CMC activities including authoring CMC section of INDs.
Interact with Contract Research Organizations as project needs evolve, which may include travel
Initiate innovative research projects to improve fundamental understanding and control of Biogen processes
Expand on your Chemistry community presence professionally representing Biogen externally in consortia and conferences

Benefits

Medical, Dental, Vision, & Life insurances
Fitness & Wellness programs including a fitness reimbursement
Short- and Long-Term Disability insurance
A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
Up to 12 company paid holidays + 3 paid days off for Personal Significance
80 hours of sick time per calendar year
Paid Maternity and Parental Leave benefit
401(k) program participation with company matched contributions
Employee stock purchase plan
Tuition reimbursement of up to $10,000 per calendar year
Employee Resource Groups participation