Director, Medical Information

Xenon Pharmaceuticals•Needham, MA

13h•Hybrid

About The Position

Xenon Pharmaceuticals is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics. We are seeking a Director, Medical Information to support the establishment, scaling, and evolution of the Medical Information (MI) function. This role drives functional priorities for, and execution of medical inquiry management, scientific response content development, contact center operations, and digital medical information capabilities to support Medical Affairs, Clinical Development, and Commercial launch readiness. The ideal candidate is a strong operational leader with a service-oriented and collaborative mindset, driven by scientific rigor, operational excellence, and cross-functional alignment to manage a scalable, future-ready MI ecosystem. This position reports to the Executive Director, Medical Information and partners closely with Pharmacovigilance & Drug Safety, Quality, Regulatory, Commercial, Market Access, Clinical Development, Legal/Compliance, and Medical Affairs. The role is critical for launch readiness and operational execution, ensuring Xenon delivers high-quality, compliant, and timely medical information. This position will be based out of Boston, MA, USA in our Needham office and is a hybrid position, requiring a minimum of 2 days per week in the office. Other jurisdictions may be considered for exceptional candidates.

Requirements

PhD, PharmD, MD, or equivalent advanced scientific degree
7+ years of management experience in Medical Affairs
Significant (5+ years) Medical Information experience
Demonstrated experience executing and optimizing Medical Information functions in pre-commercial or commercial environments
Expertise in scientific response content authoring, inquiry management, and MLR review processes
Experience engaging with/managing MI contact centers and external vendors
Strong knowledge of regulatory and compliance requirements for MI reporting (FDA, EMA)
History of leadership, strategic thinking, and operational execution skills in previous roles
Excellent communication and cross-functional collaboration skills
Experience working cross‑functionally within Med Affairs, PV/DS, Clin Dev, or related functions
Neuroscience experience preferred; epilepsy experience a plus
Strong scientific acumen, critical thinking skills, and attention to detail
Ability to manage multiple projects and collaborate effectively in a fast-paced, matrix environment
Willingness to travel up to 15-20% domestically and internationally as needed

Nice To Haves

Neuroscience experience preferred; epilepsy experience a plus

Responsibilities

Operationalize the end-to-end vision, strategy, and execution of the Medical Information function, including contact center operations, digital capabilities, and scientific content management, including readiness for commercialization and oversight of internal/external resources.
Build and deploy scalable operating models for MI, including SOPs, workflows, and governance in partnership with Legal, Compliance, PV/DS, Quality, Clin Dev, and Med Affairs.
Work with manager and Medical Affairs stakeholders to refine and execute process for the authoring and lifecycle management of Standard Response Letters (SRLs) and scientific content, ensuring accuracy, consistency, and alignment with clinical data, publications, and regulatory requirements.
Support MI alignment with enterprise efforts in omnichannel MI delivery and self-service portals.
Execute and manage MI contact center capability build including vendor selection, onboarding, training, and performance management.
Operational oversight and performance management of MI vendors (e.g., contact center, content support), including training, QA, and continuous improvement.
Work with internal company stakeholders to develop and manage a Medical Information portal to enable compliant, self-service access to approved content.
Monitor and report on tactical plan execution to ensure accurate forecasting of budget / spend, resource utilization, and anticipated executional risks.
Partner with Medical Affairs, Clinical Development, and Scientific Communications to ensure alignment of scientific messaging within the MI function.
Leverage internal and external resources to support content authoring, review and approval and ensure high-quality, consistent scientific responses.
Ensure content accuracy, consistency, and appropriate risk framing aligned with clinical data, publications, and regulatory milestones and maintain a high-quality content library.
Responsible for advancing MI materials through the MLR review processes, ensuring timely approvals and compliance.
Deliver timely, accurate, high-quality, empathetic, and patient-centered communications.
Day-to-day management of contact center vendor to ensure efficient inquiry intake, triage/escalation, fulfillment, and documentation processes aligned with regulatory standards, maintaining audit and inspection readiness of MI processes and systems.
Partner with PV/DS and Quality to ensure appropriate AE/PC identification, reporting and reconciliation.
Drive adherence to internal policies to ensure compliant handling of medical inquiries, including complex, escalated requests.
Partner with IT, Medical Ops and Commercial Ops to maintain scalable MI infrastructure.
Partner with IT, Medical Ops, and Commercial Ops to ensure MI data flows into appropriate enterprise systems and supports reporting needs.
Act as the primary operational liaison for MI contact center vendor, Med Affairs functional teams and IT project teams.
Execute and monitor MI KPIs and dashboards, supporting the translation of data into actionable insights.
Lead and manage a high-performing, outsourced Medical Information contact center team.
Provide training/feedback and oversight of contact center vendor managers and agents while fostering a culture of accountability, collaboration, and continuous improvement.
Conduct all activities in accordance with company policies, timelines, and quality standards.
Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.
Perform additional duties as assigned to support Medical Affairs objectives and evolving business needs.