Director, Immunoassay-based Biomarker Discovery and Analysis - Neuroscience

Lilly • Boston, MA

11d • $153,000 - $281,600 • Onsite

About The Position

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Requirements

• Master’s and/or PhD in Neuroscience, Biochemistry or a related scientific field, with 0-5+ years of industry, academic, or postdoctoral experience in biomarker development, with recognized expertise in immuno-assay-based methods for brain diseases.
• Must have an understanding of the principles for antibodies and other affinity-based molecules, for immunoassay design and protein biomarker quantification as well as documented hands-on experience in immunoassay development and validation for biomarker applications in clinical diagnostics, clinical trials, or preclinical sample analysis.
• Must be technically skilled to in the field of qualitative (e.g. electrophoresis techniques, Westen blot) and quantitative (e.g. ELISA, MSD, Ella, Simoa) immunoassay-based analyses.
• Excellent communication and collaboration skills, with the ability to present to influence both internal and external stakeholders.

Nice To Haves

• Proven leadership in managing and mentoring biomarker research teams in academic or industry settings.
• Experience in ultrasensitive technologies (e.g. NuLISA) and protein sepearation and purification techniques (e.g. HPLC, immunoprecipitation) is a merit.

Responsibilities

• Design, development and validation of novel immunoassay-based biomarker methods, as well as applications of these methods for early- and late-phase clinical trials in neurodegenerative diseases, including Alzheimer’s, Parkinson’s, ALS, and rare brain disorders.
• Work with project team leads, including Dr. Kaj Blennow (Vice President of Neuroscience Biomarker Development), and other associates to perform experiments to support both the preclinical and clinical characterization and evaluation of therapeutic molecules through biomarker assay development.
• Assist with the planning and execution of immunoassay method developments, method optimization and validation, as well as sample analyses from cohorts, working with both internal and external partners in complex studies.
• Work directly on-site with methods in the laboratory, and with summarizing and reporting method status of results for internal partners.
• Implement assay validation procedures to deliver high performance biomarker assays for preclinical and clinical sample analyses.
• Collaborate cross-functionally with internal stakeholders (medical, operations, statistics, regulatory) and external partners (CROs, academic institutions) to ensure biomarker validation and successful integration into clinical programs.

Benefits

• company bonus (depending, in part, on company and individual performance)
• company-sponsored 401(k)
• pension
• vacation benefits
• medical, dental, vision and prescription drug benefits
• flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
• life insurance and death benefits
• certain time off and leave of absence benefits
• well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)

What This Job Offers

• Job Type: Full-time
• Career Level: Senior