Director, Clinical Genomics Operations & Variant Science – Invitae – Remote

Labcorp•San Francisco, CA

17h•Remote

About The Position

Labcorp is seeking a US remote-based Director of Clinical Genomics Operations & Variant Science to join its Invitae Genetics division! This is a Director-level role with leadership accountability and strong operational ownership. While initially an individual contributor role, it is expected to transition into formal people management within approximately 6 months.

Requirements

PhD in Biological Sciences, Molecular Genetics, or Human Genetics with 5 years or more of related work experience; OR Master's degree in Genetic Counseling, Biological Sciences, Molecular Genetics, or Human Genetics with 6 years or more of related work experience; OR Bachelor's degree in Genetics, Biological Sciences, Molecular Genetics, or Human Genetics with 7 years or more of related work experience
3 years or more of demonstrated expertise in variant interpretation, curation, and clinical reporting for NGS-based assays, including WGS and WES and/or targeted panels. This includes current or previous hands-on variant interpretation experience
3 years or more of experience driving operational efficiency and scaling production workflows supporting clinical interpretation and/or reporting
3 years or more experience of demonstrated ability to coach, develop, and elevate operational or production teams, with strong organizational and execution skills
3 years or more of experience managing or influencing complex initiatives with measurable outcomes in a high-throughput setting
5 years or more of experience in operational leadership, including managing a team, workflow optimization, capacity planning, performance metrics, and cross-functional execution

Nice To Haves

5 years or more of Director-level experience within a CLIA-certified diagnostic laboratory or similarly regulated clinical setting
3 years or more of experience developing, launching, or scaling clinical genomic assays or interpretation programs
2 years or more of experience with rapid or NICU whole genome sequencing (NICU WGS) and high-acuity clinical workflows
2 years or more of familiarity with copy number variant (CNV) detection and interpretation across CMA and NGS-based platforms
Lean Six Sigma (Green Belt or higher) certification or equivalent continuous improvement experience
3 years or more of experience scaling high-throughput clinical interpretation/reporting operations
Background or interest in clinical domains such as oncology, cardiology, neurology, carrier screening, metabolic disorders, pediatrics, or cytogenomics
Operational leadership supporting clinical interpretation or reporting workflows, including capacity planning, quality management, and process optimization
Cross-functional collaboration with laboratory, bioinformatics, product, quality, regulatory, or clinical development teams
Experience supporting the development, launch, or scaling of clinical genomic assays or interpretation programs
Demonstrated ability to independently lead complex initiatives and influence outcomes without direct people management responsibility
Strong understanding of clinical reporting operations, quality systems, and regulated laboratory environments (e.g., CLIA, CAP)
Proven ability to operate at a Director level, balancing strategic planning with hands-on operational leadership
Strong analytical, problem-solving, and communication skills, with the ability to translate technical and operational data into executive-level insights
Demonstrated technical expertise with whole genome sequencing (WGS) and whole exome sequencing (WES), including strong understanding of clinical interpretation frameworks, reporting standards, and end-to-end workflows
Excellent written, verbal, and interpersonal communication skills
Ability to adapt to significant change that is inherent in development and

Responsibilities

Provide strategic, technical, and operational leadership for clinical interpretation and reporting across WGS, WES, targeted NGS panels, and chromosomal microarray (CMA)
Serve as subject matter expert in genomic testing workflows, interpretation frameworks, and clinical reporting standards — ensuring scientific rigor, clinical relevance, and regulatory compliance
Oversee day-to-day operational performance including production scheduling, capacity planning, process health monitoring, and escalation of operational incidents
Establish, optimize, and scale end-to-end workflows for clinical interpretation and reporting using continuous improvement methodologies
Define, implement, and monitor key operational metrics to assess performance, identify risk, and communicate trends to senior leadership
Ensure delivery of high-quality clinical reports meeting established turnaround time, accuracy, and quality benchmarks
Lead root-cause analysis and implementation of corrective and preventive actions for complex production issues
Develop and execute operational strategies aligned with broader organizational OKRs
Mentor and coach scientists, genetic counselors, and operational partners — fostering a culture of continuous learning and scientific excellence
Collaborate cross-functionally with Laboratory, Bioinformatics, Product, Quality, Regulatory, IT, and Clinical Development to support launch of new assays, tools, and initiatives
Act as an individual-contributor Director with expectation of transitioning to formal people management within ~6 months