Director, Biostatistics

Vertex Pharmaceuticals • Boston, MA

1d • Hybrid

About The Position

The Director, Biostatistics independently performs highly scientific statistical functions in support of Vertex’s Global Medicines Development and Affairs area, addressing new and complex issues with resourcefulness and self-sufficiency. The role makes independent strategic and technical contributions and applies expert knowledge of related disciplines with a drug developer mindset. As a people manager, the Director has financial accountabilities and human resource responsibilities for assigned staff.

The Director leads projects spanning multiple clinical trials, observational studies, or real-world data investigations; directs project scientific and technical strategy; and represents Biostatistics on cross-functional teams. The position involves developing statistical plans and study deliverables, guiding high-quality statistical programming, engaging with external stakeholders including regulators, and contributing to publications, posters, innovative methods, and departmental initiatives. The role also manages, mentors, and develops direct reports and supports effective cross-functional collaboration.

Requirements

• Ph.D. or master’s degree in Statistics or Biostatistics.
• Typically 10 years of experience with a Ph.D., 13 years with a master’s degree, or an equivalent combination of education and experience.
• Project management and project team oversight skills.
• Expertise with SAS and R statistical software.
• Demonstrated expertise in advanced or complex statistical methods used in drug development.
• Strong critical-thinking and logical problem-solving skills.
• Excellent written and verbal communication skills, including the ability to influence peers and managers.
• Ability to excel in a team environment and collaborate with non-statisticians, explaining complex concepts to non-technical audiences.
• NDA/MAA experience and direct dealings with U.S. and European regulators.

Nice To Haves

• Curiosity and sound judgment in evaluating advances in AI, technology, automation, and industry trends.
• Ability to thoughtfully adopt new capabilities to improve decision-making, drive innovation, increase efficiency, and support better patient outcomes.

Responsibilities

• Directs one or more projects involving multiple clinical trials, observational studies, or real-world data investigations, including presentations to the Peer Protocol Review Committee or other internal senior review boards.
• Manages direct reports, including their performance and professional development.
• Mentors project team members and promotes effective team operation and cross-functional collaboration.
• Represents Biostatistics on cross-functional teams, providing strategic input and expert technical guidance.
• Sets the technical and scientific direction of assigned projects.
• Authors study Statistical Analysis Plans, including table, figure, and listing shells.
• Develops Cross-functional Data Review plans, Key Reports Memos, and Data Dissemination Plans to support review, summary, and dissemination of study data and results.
• Leads collaboration with statistical programming and other functions to ensure high-quality, technically sound delivery of tables, figures, and listings.
• Leads or contributes to external interactions with regulators, payers, review boards, and other stakeholders.
• Authors or co-authors methodological or study-related publications and posters.
• Leads implementation of innovative designs and analysis methods at the study or project level.
• Participates in Statistical Review Forum discussions of studies assigned to others.
• Contributes to departmental working groups addressing technical and operational issues.
• Independently addresses new and highly complex issues, developing alternative approaches to achieve desired results.
• Maintains and expands in-depth knowledge of related disciplines with a drug developer mindset.

Benefits

• Annual bonus eligibility
• Annual equity awards
• Medical insurance
• Dental insurance
• Vision insurance
• Generous paid time off, including a week-long company shutdown in summer and winter
• Educational assistance programs, including student loan repayment
• Commuting subsidy
• Matching charitable donations
• 401(k)

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Education Level: Ph.D. or professional degree