Computational Research Scientist in Yang Lab

St. Jude Children's Research Hospital • Memphis, TN

7d • Onsite

About The Position

The Yang laboratory at the Center of Excellence for Structural Cell Biology at St Jude Children’s Research Hospital invites applications for a Scientist position to contribute to the development of cryogenic correlative light and electron microscopy (cryo-CLEM). Cryo-CLEM leverages fluorescent signals to identify regions of interest and integrates cryo-electron microscopy/tomography to obtain high-resolution structural information from those same locations in their native, hydrated state. Despite significant progress in the field, current cryo-CLEM workflows remain labor-intensive and often suffer from low throughput and limited precision. Our group specializes in in situ cryo-ET and in developing tools and workflows for efficient, accurate 2D/3D multimodal cryo-CLEM. We seek a highly motivated individual interested in developing innovative computational and imaging solutions to enhance the accuracy, robustness, and efficiency of 2D/3D correlative workflows. Performs and/or coordinates a wide range of laboratory research procedures and conducts a spectrum of complex support tasks and projects determined by the field and scope of the particular research study. Performs a variety of laboratory techniques independently and presents results.

Requirements

• Advanced Degree (Preferably Ph.D.) in engineering, computational science, or related discipline
• Expertise in machine learning and computer vision
• Proficiency in program languages in Python, R, JavaScript, Git, Linux, MATLAB
• Strong problem-solving skills and the ability to design, execute and interpret computational and or imaging experiments
• Motivation to learn new techniques and adapt to evolving technological needs
• Ability of thrive in a multidisciplinary, collaborative environment with a respectful and team-oriented approach
• High level of self-motivation, organization, and commitment to achieving project goals
• Excellent oral and written communication skills
• Bachelor's degree in Bioinformatics, Molecular Biology, Biochemistry, Computer Science, or related field required.
• Master's degree or PhD preferred.
• Minimum Requirement: Bachelor's degree and 6+ years of relevant experience.
• Experience Exception: Master's degree and 4+ years of relevant experience (OR) PhD with no experience.
• Rough criteria for this position based on publication output: 1-2 first author papers IF >5 (or equivalent contribution to other research outputs).

Nice To Haves

• Prior experience with image analysis and handling and software/tool development for workflow optimization is a plus
• Prior experience in computational research techniques preferred.
• Experience in project coordination, maintenance, and other research support activities preferred.

Responsibilities

• Lead computationally focused scientific research projects with moderate supervision from their PI.
• Provide inputs regarding analytical approaches, set up analyses, and can develop new computational research methods with input from PI.
• Identify, process, organize, summarize, review, and report relevant data.
• Draft a manuscript and work through the submission and review process with input from the PI, as directed.
• Instruct and provide guidance to other staff in basic computational research techniques and procedures.
• Perform other duties as assigned to meet the goals and objectives of the department and institution.
• Maintains regular and predictable attendance.

Benefits

• world-class high-resolution multimodal imaging and structural cell biology infrastructure
• dedicated high performance computing (HPC) system
• multiple Krios TEMs
• advanced cryo-FIB-SEM systems including Hydra-bio, Arctics, and Aquilos II with integrated fluorescence
• Zeiss Air-scan cryo-CLEM system
• plunge freezing systems including Vitrobot Mark IV, EMGP-2
• high pressure freezing systems
• exceptional environment for interdisciplinary research in imaging, computation, and structural biology
• Compensation: $86,320 - $154,960 per year

What This Job Offers

• Job Type: Full-time
• Career Level: Senior