Co-op: Off-Target Analysis of Gene Editing
About The Position
Prime Medicine is seeking a highly motivated co-op to join the Off-target biology team supporting Prime Editing programs. This role will contribute to the safety evaluation of Prime Medicine’s gene editing therapies. The candidate will work at the interface of cell biology, genome editing, next-generation sequencing (NGS), and Molecular Biology. The coop will work with a scientist to support their off-target analysis of pre-clinical gene editing programs. This will include, cell biology, molecular analysis of Prime Editing components, and next generation sequencing of Prime Editing outcomes. In addition to supporting ongoing work the Co-op will be able to develop a defined project and will work closely with other teams such as Computational Sciences and Screening. This position offers hands-on experience with cutting-edge gene editing technologies in a fast-paced, collaborative R&D environment focused on developing transformative genetic medicines. We seek a driven team member passionate about advancing human health.
Requirements
- Pursuing a B.S. or M.S. in Molecular Biology, Genetics, Bioengineering, or related field
- Hands-on experience with core molecular biology techniques, including PCR and DNA extraction
- Experience with aseptic technique
- Familiarity with genome editing concepts
- Exposure to NGS workflows or sequencing-based assays
- Strong attention to detail, troubleshooting ability, and collaborative mindset
Nice To Haves
- Prior mammalian cell culture experience strongly preferred
- Hands-on experience with gene editing and/or NGS techniques
- Experience with laboratory automation and/or data analysis
Responsibilities
- Perform cell transfections and execute gene editing experiments
- Isolate genomic DNA, prepare NGS libraries, and operate Illumina sequencing platforms
- Analyze PE activity in cells including ELISAs and other assays
- Maintain cell lines in culture and become adept at cell handling
- Analyze and interpret sequencing data
- Maintain accurate experimental documentation using an electronic lab notebook system
Benefits
- Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks.
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What This Job Offers
Career Level
Intern
