Co-op, Downstream Process Development

Ultragenyx PharmaceuticalWoburn, MA
Onsite

About The Position

We are seeking a motivated undergraduate or graduate student to join our AAV Downstream Process Development team. The successful candidate will support laboratory and data ‑ driven activities that directly contribute to commercial manufacturing, process development, and clinical compatibility studies. This position offers hands ‑ on experience in gene therapy downstream purification, exposure to GMP ‑ aligned development workflows, and the opportunity to learn industry ‑ relevant skills in chromatography, buffer preparation, and data analysis. This role typically requires that the majority of the work be conducted on-site and thus will be subject to certain on-site safety protocols during the pandemic.

Requirements

  • Currently pursuing a bachelor’s or master’s degree in chemical engineering, Bioengineering, Biotechnology, Biology, Biochemistry, or a related scientific field.
  • Strong interest in bioprocessing, AAV/gene therapy, or downstream purification.
  • Ability to perform experimental studies on multiple AAV programs.
  • Ability to follow protocols carefully and maintain attention to detail.
  • Basic laboratory experience (academia or industry) preferred; chromatography or filtration exposure is a plus.
  • Familiarity with Excel, data entry, or simple data analysis tools is advantageous.
  • Strong communication skills, willingness to learn, and a team ‑ oriented mindset.

Nice To Haves

  • chromatography or filtration exposure

Responsibilities

  • Support development activities for AAV downstream processes, including buffer screening, filtration studies, and chromatography evaluations.
  • Perform routine laboratory experiments under supervision, maintain detailed electronic lab notebook entries, and present results in team meetings.
  • Conduct laboratory studies to support commercial manufacturing needs, including column and resin lifetime extension studies required.
  • Assist with investigations by providing experimental support, data review, or lab-based troubleshooting as needed.
  • Contribute to clinical in ‑ use compatibility studies, supporting material preparation, sample handling, and execution of defined protocols (as needed).
  • Prepare buffers and solutions according to established procedures to support ongoing experiments and team operations.
  • Participate in core lab activities, including inventory management, equipment maintenance, and general lab organization.
  • Assist with data entry and trending of manufacturing datasets.
  • Support data management by compiling, organizing, and formatting process data.

Benefits

  • Generous vacation time and public holidays observed by the company
  • Volunteer days
  • Long term incentive and Employee stock purchase plans or equivalent offerings
  • Employee wellbeing benefits
  • Fitness reimbursement
  • Tuition sponsoring
  • Professional development plans
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