Clinical Trial Manager (CTM or Sr. CTM)

Acrivon Therapeutics•Watertown, MA

2d•$135,000 - $180,000•Onsite

About The Position

The Clinical Trial Manager (CTM / Sr. CTM) will be a key member of Acrivon Therapeutics’ Clinical Operations Team and will be responsible for providing oversight to the ARC-386 Phase II clinical trial. This position will be based in Watertown, MA. The Clinical Trial Manager position focuses on strategic planning, implementation, and management of a complex clinical trial. Dedicated to overseeing trials from start-up through close-out, fostering relationships with investigator sites, vendors, cross-functional colleagues, and consultants to ensure GCP/ICH compliance and timely deliverables.

Requirements

Minimum of a bachelor’s degree in a scientific or health-related discipline.
Minimum of 3+ years of Clinical Operations and Clinical Trial Management experience at a contract research organization, biotech or pharmaceutical company preferably in early to mid-phase oncology
Proven leadership skills managing cross-functionally in a matrix environment.
Demonstrated ability to build strong relationships with internal / external partners, CROs, and vendors including extensive experience managing contracts and clinical finance activities.
Mature, level-headed and organized with a can-do disposition.
Strong verbal and written communication skills with ability to communicate and work productively in a team environment.
Proficient computer skills i.e. Microsoft Project, Word, PowerPoint, and Excel
Proven ability to multi-task and work collaboratively as well as independently.
Ability to organize and manage multiple priorities required.

Responsibilities

Oversees site initiation, subject enrollment, clinical monitoring, compliance at clinical sites, and metrics management with CROs, central labs, and external vendors.
Ensures high-quality execution throughout clinical trial initiation, conduct, and closure.
Manages study budgets, contracts with vendors, and negotiates agreements to track and control costs effectively.
Guides cross-functional teams in achieving study timelines, strategies, goals, and quality benchmarks.
Evaluates and ensures effective oversight of Contract Research Organizations (CROs) and other vendors, fostering strong partnerships and accountability.
Communicates effectively with study team and sites to maintain project momentum, direction and team effectiveness.
Updates stakeholders on trial progress to align expectations, priorities, and deliverables.
Contributes to study-level budget development and takes responsibility for budget management.
Identifies and addresses risks associated with clinical studies and investigator sites, implementing corrective actions or escalations as needed.
Lead operational activities detailed in study plans, SOPs, and other study-related documents.
Reviews / contribute to critical study documents, including protocols, manuals, informed consent forms, and operational materials.
Assesses monitoring visit reports to verify site training adequacy and resolve any outstanding issues promptly.
Lead study team’s cross-functional vendor oversight efforts.