Manager or Sr. Manager, Clinical Trial Feasibility Lead

Kymera Therapeutics•Watertown, MA

31d•$115,000 - $215,000

About The Position

Kymera Therapeutics is seeking a Manager or Senior Manager, Clinical Trial Feasibility Lead to own feasibility assessments and country and site strategy within the Trial Optimization function. The role leads feasibility for clinical studies across the portfolio, partnering with cross-functional study teams, Development Operations, and CRO partners to ensure protocols, country and site plans, and enrollment assumptions are realistic, evidence-based, and executable. The position uses patient population and epidemiology information, site and investigator insights, historical study experience, and competitive trial landscape research to inform study planning. The Feasibility Lead turns findings into clear recommendations that improve the speed and predictability of clinical trial execution. The role reports to the Director of Clinical Trial Planning and Feasibility.

Requirements

Bachelor's degree in Life Sciences, Public Health, or a related field.
At least 5 years of experience for Manager level or 7 years for Senior Manager level in clinical operations, clinical trial feasibility, site selection, or study start-up within the biotechnology, pharmaceutical, or CRO industry.
Demonstrated experience leading or contributing to clinical trial feasibility assessments, including country and site selection and recruitment planning.
Strong knowledge of clinical trial operations, site activation, and the drug development process.
Experience working with CROs and vendors on feasibility, site identification, and site selection activities.
Experience conducting competitive landscape research using sources such as ClinicalTrials.gov, scientific publications, conference presentations, and regulatory announcements.
Familiarity with ICH-GCP and global regulatory and country-specific considerations that affect study start-up and enrollment.
Strong communication and influencing skills, with the ability to partner effectively across functions and with external investigators and CRO partners.
Ability to manage multiple priorities in a fast-paced environment.
Curiosity and a proactive approach to identifying opportunities and risks.

Nice To Haves

An advanced degree.
Experience supporting immunology or inflammation clinical development programs.
Experience with clinical trial intelligence and site data tools such as GlobalData or TrialTrove, or similar tools, and CTMS or other clinical systems.

Responsibilities

Lead end-to-end feasibility for clinical studies, from early protocol concept through site selection, assessing recruitability, patient availability, site capacity, and operational risk.
Develop country and site recommendations, including country allocation, site footprint, and site selection criteria, with Clinical Operations and CRO partners.
Oversee CRO and vendor site feasibility activities, including site and investigator outreach, feasibility questionnaires, and evaluation of site capabilities, patient access, and relevant study experience.
Establish and communicate enrollment and recruitment assumptions, including enrollment timelines, screen failure and dropout expectations, and site activation plans; define feasibility risks and mitigation strategies.
Assess the competitive clinical trial landscape, including competing studies, patient and site competition, and treatment landscape dynamics that may affect feasibility and enrollment.
Partner with the Kymera Site Engagement team to obtain real-world insight into patient populations, standard of care, and site operations.
Monitor study performance against feasibility assumptions, including enrollment and site activation, and work with study teams and CROs to identify emerging risks and recommend recruitment and contingency strategies.
Capture lessons learned and compare planned with actual trial performance to improve feasibility assumptions, site selection practices, and future study planning.
Partner with Clinical Operations, Medical Development, Program Management, and other stakeholders to align feasibility questions, priorities, and timelines.
Contribute to the development and continuous improvement of feasibility processes, standards, and best practices.