Clinical Scientist Director

AstraZeneca•Boston, MA

1d•$203,710 - $305,564•Hybrid

About The Position

The Clinical Scientist Director leads the scientific design, delivery, and interpretation of pivotal late-stage clinical studies in immunology, helping determine benefit, risk, and value and supporting evidence-based decisions throughout development. The role partners closely with the study physician and cross-functional colleagues to uphold trial integrity, data quality, and safety evaluation, and to guide regulatory strategy and program direction from first patient in through submission. The position provides scientific leadership across one or more programs, with responsibility for Phase IIb and Phase III trial strategy and design, evidence generation, data review, safety evaluation, and support for medical monitoring. It contributes scientific expertise to regulatory documents and interactions, therapeutic-area standards, strategic decisions, and communications with governance groups, investigators, and other stakeholders. The role is based on an office-working model averaging at least three days per week in person, with flexibility. AstraZeneca plans to move to Kendall Square/Cambridge in 2026. The annual base pay range is $203,709.60–$305,564.40 USD. The position is eligible for short-term incentive bonuses and equity-based awards. Benefits include qualified retirement programs, paid time off (including vacation, holidays, and leaves), and health, dental, and vision coverage, subject to applicable plan terms.

Requirements

Scientific doctoral-level degree (e.g., PhD or PharmD), relevant equivalent clinical qualification, or another relevant university degree with extensive clinical-development experience.
At least five years of relevant pharmaceutical-industry experience, including multi-country clinical trials.
Understanding of scientific and clinical issues in clinical-trial design, implementation, and interpretation of results, particularly in immunology clinical development.
Proven ability to collaborate in a cross-functional setting.
Experience in Phase II and Phase III clinical development.

Nice To Haves

Experience with regulatory submissions.
Experience with lifecycle management.
Experience with advisory boards.
Experience with annual safety updates.

Responsibilities

Lead innovative Phase IIb and Phase III trial designs that address decisive scientific and clinical questions aligned with program strategy.
Provide clinical and scientific guidance across one or more programs, including development of hypotheses, endpoints, and evidence plans.
Define study quality metrics and data review plans; monitor trends to protect data integrity and identify actionable insights.
Coordinate end-to-end safety evaluation for pivotal trials with Patient Safety and study physicians to anticipate, detect, and manage risk.
Collaborate with Clinical Operations, Biostatistics, Regulatory Affairs, Patient Safety, and early development teams to deliver trials across geographies.
Provide expert input to protocols, informed consent forms, investigator’s brochures, and clinical study reports; contribute to regulatory packages and engage with health authorities.
Support medical monitoring to uphold patient safety, protocol fidelity, and data quality during trial conduct.
Analyze ongoing-study and literature data and synthesize evidence for go/no-go decisions, label-enabling strategies, and lifecycle planning.
Contribute scientific input to therapeutic-area standards and promote consistency and excellence across studies.
Provide scientific evidence to guide R&D, marketing, clinical, and business development decisions.
Present protocols and scientific results to governance groups, investigators, and key stakeholders; communicate clear narratives that support decisions.
Organize and analyze clinical research to generate hypotheses and shape future studies, collaborating with late-stage and early-development colleagues and medical affairs.