Clinical Research Coordinator I

Mass General Brigham•Boston, MA

1d•$29•Onsite

About The Position

This Clinical Research Coordinator I role is embedded in Dr. Vamsi Mootha’s laboratory—with Dr. Mootha serving as the lead PI of the Mitochondrial Medicine Unit—and operates under the clinical direction of Dr. Walker (Neurology) and Dr. Sharma (Medicine) to advance translational research in mitochondrial disease. The position integrates human‑subject activities with bench‑based methods (e.g., clinical procedures and core molecular techniques). In addition to the baseline CRC I responsibilities, the position requires laboratory competencies central to mitochondrial research, including human biospecimen processing and handling, basic cell culture, and molecular assays such as qPCR and ELISA, enabling direct linkage between clinical phenotypes and bench‑based analyses. The role also entails management of a disease‑specific research registry and biorepository—with responsibilities for aliquoting, coding, long‑term storage, and compliant shipping—to ensure high‑quality, retrievable samples for current and future studies. Programmatic and collaborative expectations include presenting progress in weekly meetings, assisting with conferences such as the MitoCase seminar series, and providing administrative support for educational initiatives of the MGH Mitochondrial Medicine Unit, thereby extending impact beyond individual studies. The coordinator will partner with national patient‑advocacy organizations (e.g., UMDF, Mito‑Action, FARA) and coordinate across multiple institutions, activities that are essential to advancing research in rare mitochondrial disorders. Finally, the position provides regulatory support at a level commensurate with complex rare‑disease research, including QA/QC, proof‑reading of regulatory and scholarly documents, and assistance with submissions up to and including Expanded Access/Compassionate Use IND protocols.

Requirements

Direct and demonstrable experience across all of the above domains—including mitochondrial or related molecular biology techniques, biospecimen handling, biorepository operations, and rare‑disease research coordination—in order to successfully fulfill the responsibilities of this role.
Bachelor's degree with 3–12 months of prior mitochondrial molecular biology or similar bench research experience.
Prior record‑keeping, archival, or patient‑interaction experience.

Responsibilities

Reviews proposals for compliance with sponsor and organizational guidelines; verifies that all sponsor requirements are met.
Recruiting patients for clinical trials and conducting phone interviews.
Verifies the accuracy of study forms and updates them per protocol.
Prepares data for analysis and data entry.
Documents patient visits and procedures.
Assists with regulatory binders and QA/QC Procedures.
Assists with interviewing study subjects.
Assists with study regulator submissions.
Human biospecimen processing and handling.
Basic cell culture.
Molecular assays such as qPCR and ELISA.
Management of a disease‑specific research registry and biorepository.
Aliquoting, coding, long‑term storage, and compliant shipping of samples.
Presenting progress in weekly meetings.
Assisting with conferences such as the MitoCase seminar series.
Providing administrative support for educational initiatives of the MGH Mitochondrial Medicine Unit.
Partnering with national patient‑advocacy organizations.
Coordinating across multiple institutions.
Providing regulatory support for complex rare‑disease research.
Proof‑reading of regulatory and scholarly documents.
Assistance with submissions up to and including Expanded Access/Compassionate Use IND protocols.