Clinical Medical Monitor

Praxis Precision Medicines, Inc.

10d•$260,000 - $335,000•Remote

About The Position

Great clinical development depends on strong medical judgment in the moments that matter: when an investigator has a question, a safety event needs assessment, or emerging data require action. At Praxis, you’ll provide hands-on medical oversight for assigned clinical programs, with patient safety and study quality at the center. You’ll support investigators and sites on eligibility, dosing, safety events, and other medical questions; review clinical and safety data; assess serious adverse events; and identify emerging signals or trends. You’ll partner closely with clinical leads and cross-functional study teams while maintaining independent medical judgment. This is a role for someone who wants to stay close to the patients, sites, and data and make timely, thoughtful decisions that keep studies moving safely and effectively.

Requirements

MD or equivalent medical degree required
Clinical trial experience with responsibility for medical monitoring, clinical safety, or related medical oversight.
Strong clinical judgment and demonstrated ability to assess AEs and SAEs consistently and rigorously.
Experience responding to investigator and site medical questions and making timely decisions when information is incomplete.
Ability to review clinical data, recognize meaningful patterns or potential safety signals, and determine when action or additional surveillance is needed.
Working knowledge of GCP, clinical trial safety reporting requirements, and documentation standards.

Nice To Haves

CNS or relevant therapeutic area experience preferred.

Responsibilities

Provide timely medical guidance for assigned studies, including eligibility, dosing, protocol requirements, safety events, and other study-related medical questions.
Review AEs and SAEs, assessing causality, severity, expectedness, clinical significance, and potential implications for patients and the program.
Respond promptly and consistently to investigator and site medical questions, balancing patient safety, protocol requirements, and sound clinical judgment.
Review patient-level and aggregate clinical and safety data to identify trends, inconsistencies, emerging signals, and areas requiring follow-up.
Ensure medical monitoring, safety assessment, escalation, and documentation meet applicable regulatory requirements, GCP standards, and study protocols.
Work closely with clinical development, clinical operations, safety/pharmacovigilance, biostatistics, data management, and regulatory colleagues to resolve issues and support high-quality study execution.
Bring a clear medical perspective to decisions, challenge assumptions when warranted, and know what to escalate and when.