Chemist/Sr. Chemist - Materials Science and Physical Characterization

Eli Lilly and Company • Us, IN

1d • Onsite

About The Position

The solid-state analytical scientists are responsible for the analytical efforts to support development and scale-up of investigational small molecules to support clinical trials from Candidate Selection through late-stage clinical trials (Phase III). Through application of scientific training and relevant experience, the individual will be responsible for working with a team of scientists to develop a phase-appropriate analytical control strategy to support the development and commercialization of new drug candidates. The individual will apply their expertise in materials science and powder characterization to establish physical property control strategies for active pharmaceutical ingredients, drug product intermediates, and drug products, provide solid-state characterization to support analytical investigations, and develop solutions for physical property and material science-related technical challenges.

Requirements

• B.S. or M.S. in a related field OR demonstrated equivalent experience in a related field of expertise.
• Expertise in solid-state characterization and associated analytical techniques with M.S. and 5+ years’ experience, or B.S. and 6-7+ years' experience, in the pharmaceutical industry.
• Proficient in establishing solid-state analytical methodologies to support characterization of pharmaceutical powders and drug products.
• Experience using solid-state instrumentation including X-ray powder diffraction (identification, limit and quantitative), particle size analysis, surface area analysis, thermal analysis, optical microscopy, spectroscopy (e.g. FTIR and Raman), powder flow techniques, moisture sorption, and Porosimetry techniques.
• Familiarity in testing of amorphous solid dispersion materials, intermediates, and drug products.
• Strong experience in making amorphous materials and measuring the impact of the glass transition by solvent and water ingress using dynamic vapor sorption, differential scanning calorimetry, and dynamic mechanical analysis techniques.
• Demonstrate the ability to identify scientific issues, make decisions and solve problems, both individually and with partners in functional groups.
• Demonstrates strong written and verbal communication skills.

Nice To Haves

• Strong working knowledge of SEM including SEM-EDS and sTEM preferred.
• Assists in the preparation of appropriate portions of regulatory submissions.
• Proficient with Microsoft Office software programs.
• Experience with TA Instruments TRIOS, Malvern Mastersizer, Bruker EVA and DQuant, ThermoFisher OMNIC preferred.

Responsibilities

• Participates in the design and development aspects of drug substance and/or drug product.
• Development and refinement of solid-state analytical methodologies to support characterization of pharmaceutical powders and drug products and subsequent transfer to third parties.
• Assist in innovating and helping to create novel solutions to difficult problems.
• Establish effective networks with other engineers and scientists within and external to Lilly to leverage other capabilities for the department.
• Deliver timely, high-quality data and interpretations to drive key scientific solutions.
• Develops plans and assists in setting group goals and timetables for project work.
• Communicates progress and proposed changes in project timetables, objectives, or direction.
• Communicates and collaborates with coworkers and management to meet project team goals and promote technical excellence.
• Properly documents development work and adequately maintains laboratory notebooks and records.
• Assists in preparation of technical reports or authors technical reports.
• Document results in consistent and timely manner to protect Lilly's intellectual property and provide valuable information to others internally or externally, as needed, to meet regulatory requirements.
• Maintains an awareness of the proper use and maintenance of laboratory equipment in the development facility.
• Properly addresses safety and environmental issues.
• Understands and complies with corporate, divisional, and departmental procedures, including good manufacturing practices, safety, and other applicable regulations.

Benefits

• company bonus
• company-sponsored 401(k)
• pension
• vacation benefits
• medical, dental and vision benefits
• prescription drug benefits
• flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
• life insurance and death benefits
• certain time off and leave of absence benefits
• well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Associate degree
• Number of Employees: 5,001-10,000 employees