Chemist II

Bureau Veritas•Boston, MA

2d•$36 - $40•Onsite

About The Position

The Chemist II is responsible for assisting with synthesis and downstream processing of oligo synthesis using various analytical techniques. FPLC (Fast Protein Liquid Chromatography, HPLC, LCMS and other analytical instruments are used. This person will work on multiple projects simultaneously and stay current with new modifications of oligonucleotides.

Requirements

Experience with laboratory techniques and equipment (pipetting, mass spectrometry, chromatography) is required
Basic understanding of chemistry, stoichiometry and chemical synthesis
Strong organizational skills and time management skills
Effective communication skills for collaborating with team members and conveying technical information clearly.
Strong problem-solving abilities and critical thinking skills
Ability to organize and prioritize workload to meet or exceed deadlines
Individual and Team work ethic
Proficiency with Windows, Word & Excel
Strong attention to detail and ability to follow protocols precisely
Positive attitude, self-motivated, high level of engagement
Eagerness to learn and adapt in a fast paced environment
Champions and adheres to company values including team engagement

Nice To Haves

Hands on experience in solid phase oligonucleotide synthesis is a plus
Strong laboratory skills and experience with analytical instrumentation such as AKTA, Agilent LC-MS and UPLC, Vanquish LTQ, Water’s QDA, etc.
Experience with oligonucleotides helpful

Responsibilities

Assist in the synthesis of oligonucleotides using automated synthesizers, following established protocols, ensuring accuracy in reagent preparation and reaction conditions.
Perform purification of oligonucleotides using techniques such as FPLC and HPLC and monitoring purification processes to achieve high quality results.
Conduct analytical assays to verify the quality and identity of synthesized oligonucleotides using LC-MS
Maintain accurate and detailed records of experiments, procedures, and results. Ensure all documentation is compliant with company standards and regulatory requirements.
Contribute to the maintenance of the laboratory.
Work closely with senior chemists and other team members to support ongoing projects.
Use of general laboratory equipment including but not limited to pipettors, centrifuges, incubators, biological safety cabinets and balances
Familiarity with various statistical analysis tools and able to solve technical problems and make recommendations for improvement
Work closely with members of the RNAi scale up chemistry team to understand and validate requirements for synthesis scaleup and downstream processing
Review literature to stay current on new methods for oligonucleotides and provide technical solutions to clients and management
Detailed record keeping of daily experiments in ELNs
Identify, troubleshoot, and suggest technical solutions to clients and management
Follow the guidelines set forth with clients and Company Quality, Health, Safety, Security and Environmental policies and procedures.
Comply with clients’ and Company management systems in accordance with appropriate regulatory agencies.
Other duties as defined by the Manager, department needs and workload