Cellular Biologist II, Global Stem Cell Array

The Jackson Laboratory•New York, NY

13h•$73,382 - $82,311•Onsite

About The Position

The Cellular Biologist II, Global Stem Cell Array, performs project planning, experimental design, method development, execution of laboratory procedures, adaptation of protocols, data collection and analysis, documentation, and contribution to reports and other written materials for human/mammalian cell culture. Primary responsibilities include implementing and performing cell biology related tasks and procedures; planning and monitoring resources needed to conduct tasks such as the cell culture (manual or automated), spatial transcriptomics, and hyperplexed imaging technologies of the laboratory; maintaining inventory control; coordinating space, field, equipment, and/or facilities; may monitor expenditures; documentation of results; implementing protocols from the literature; identifying problems, troubleshooting, and analyzing variations observed and reported in regular testing protocols; modifying, refining, or adapting techniques and procedures; modifying and/or adjusting quality control measures; leading exchange of research information through demonstration and instruction; performing and independently monitoring automated and manual cell culture and related activities; adapting protocols and developing new workflows with periodic support as required; working collaboratively to perform all necessary protocols for workflows that include, but are not limited to, fibroblast expansion, reprogramming, iPSC expansion on the robotic platform(s), or manually as required; storing and withdrawal of specimens from liquid nitrogen and freezers and prepare media and reagents required for daily work; working closely with the laboratory operations team to ensure reagent/consumable inventory is accurately and efficiently stocked; planning and monitoring resources needed to operate the Global Stem Cell Array; maintaining inventory control; coordinating space and field questions; may be required to participate in the monitoring and tracking of resources/expenditures across projects; working closely with departmental leadership and a multidisciplinary team of scientists and technical specialists; and providing documentation and feedback including the creation and modification of SOPs, filing of file tickets to software and automation teams, and providing feedback at inter- and intra-team meetings. The role will be in regular collaboration with cross functional partners such as project managers, engineering teams, and software or technical support personnel to ensure smooth day-to-day laboratory operations in a production focused environment and will collaborate with engineers and other staff when resolving more complex issues.

Requirements

Bachelor’s degree or foreign equivalent in a directly related specialty of biology, such as biotechnology, forensic science, or biology.
Two years of experience in a professional laboratory scientific role performing both automated and manual cell culture operations for induced pluripotent stem cell (iPSC) lines in compliance with Laboratory Information Management Systems.
Experience with Automated iPSC Derivation and Cell Culture Operations including production and handling of biological materials to support automated induced pluripotent stem cell (iPSC) reprogramming, expansion, maintenance and assay execution, including robotic media exchange, passaging, thawing, and cryopreservation (over a period of 24 months).
Experience with Processing whole blood, skin, saliva, and fibroblast samples; isolation of PBMCs using manual and automated array systems; preparation of biological inputs for downstream reprogramming and discovery workflows within Laboratory Information Management Systems platforms (over a period of 24 months).
Experience with Executing fibroblast reprogramming protocols, initiation of stem cell discovery pipelines, and transition of primary cell types into pluripotent states under controlled manual and automated conditions (over a period of 24 months).
Experience with Implementation, development, and continuous improvement of novel automated assays and workflows; analysis and assessment of robotic system performance; identification and resolution of automation related process issues affecting biological sample production (over a period of 24 months).
Experience with Maintenance of organized, accurate records; independent troubleshooting with concise error reporting to scientific teams; exclusive use of the Laboratory Information Management Systems tracking system for sample and process traceability (over a period of 24 months).

Responsibilities

Performs project planning, experimental design, method development, execution of laboratory procedures, adaptation of protocols, data collection and analysis, documentation, and contribution to reports and other written materials for human/mammalian cell culture.
Implements and performs cell biology related tasks and procedures.
Plans and monitors resources needed to conduct tasks such as cell culture (manual or automated), spatial transcriptomics, and hyperplexed imaging technologies.
Maintains inventory control.
Coordinates space, field, equipment, and/or facilities.
May monitor expenditures.
Documents results.
Implements protocols from the literature.
Identifies problems, troubleshoots, and analyzes variations observed and reported in regular testing protocols.
Modifies, refines, or adapts techniques and procedures.
Modifies and/or adjusts quality control measures.
Leads exchange of research information through demonstration and instruction.
Performs and independently monitors automated and manual cell culture and related activities.
Adapts protocols and develops new workflows with periodic support as required.
Works collaboratively to perform all necessary protocols for workflows that include, but are not limited to, fibroblast expansion, reprogramming, iPSC expansion on the robotic platform(s), or manually as required.
Stores and withdraws specimens from liquid nitrogen and freezers and prepares media and reagents required for daily work.
Works closely with the laboratory operations team to ensure reagent/consumable inventory is accurately and efficiently stocked.
Plans and monitors resources needed to operate the Global Stem Cell Array.
Coordinates space and field questions.
May be required to participate in the monitoring and tracking of resources/expenditures across projects.
Works closely with departmental leadership and a multidisciplinary team of scientists and technical specialists.
Provides documentation and feedback including the creation and modification of SOPs, filing of file tickets to software and automation teams, and providing feedback at inter- and intra-team meetings.
Collaborates with cross-functional partners such as project managers, engineering teams, and software or technical support personnel to ensure smooth day-to-day laboratory operations in a production focused environment.
Collaborates with engineers and other staff when resolving more complex issues.