Cell Delivery and Formulation Scientist

Battelle•Columbus, OH

7d•Hybrid

About The Position

Battelle is seeking a curious and passionate scientist to lead intracellular delivery and formulation development for a biostabilization platform. In this role, you will design and execute high-throughput screening campaigns, integrate delivery and formulation strategies, and collaborate across a multi-institution team of academic and commercial partners. This position offers direct ownership of a core technical thrust within a high-impact, federally funded program, providing a unique opportunity to drive meaningful scientific advancement at the intersection of cell biology, bioengineering, and translational research.

Requirements

Ph.D. in Bioengineering, Biomedical Engineering, Mechanical Engineering, Chemical Engineering, Cell or Molecular Biology, Biophysics, Materials Science, or a related field with 0–2 years of experience; or an M.S. with 2+ years of relevant experience
Demonstrated experience in intracellular delivery or cell membrane permeabilization using one or more physical or non-viral methods (e.g., microfluidic cell squeezing/mechanoporation, electroporation or nucleofection, sonoporation, microinjection, nanoneedle/nanostraw, or comparable techniques)
Hands-on expertise in mammalian cell culture, including primary cells and cell lines, and sterile technique
Experience developing and running quantitative cell-based assays (viability, cytotoxicity, apoptosis, metabolic activity) and flow cytometry
Experience formulating and optimizing biological formulations or protectants, or a strong foundation in formulation science
Strong data analysis skills with the ability to define and apply acceptance criteria
Strong analytical, organizational, and written and verbal communication skills; ability to work independently and lead within a multidisciplinary team
Applicants must have authorization to work in the United States. We are unable to sponsor or take over sponsorship of any employment Visa at this time.

Nice To Haves

Experience with cell stabilization technologies such as desiccation, cryopreservation, or lyophilization
Familiarity with protectant biology and anhydrobiosis
Experience with high-throughput screening, automated liquid handling, and design of experiments (DOE)
Proficiency with data analysis tools (e.g., GraphPad Prism, R, Python, FlowJo)
Track record of peer-reviewed publications or conference proceedings
Experience with cell and gene therapy products or manufacturing (e.g., CAR-T, stem cell, or other cell-based therapeutics)

Responsibilities

Develop and optimize intracellular delivery of cargo into multiple mammalian cell types, including parameter development on reference delivery systems
Design, formulate, and optimize cocktails for cell stabilization and recovery
Plan and execute high-throughput screening of delivery and formulation conditions using automated liquid handling, plate-based viability and metabolic assays, and flow cytometry
Define quantitative acceptance criteria; analyze viability, apoptosis, metabolic activity, and recovery data; and drive down-selection of lead conditions
Coordinate technical execution with academic and commercial partners, including transfer of protocols and materials
Author technical reports, standard operating procedures, and program deliverables; present results to internal leadership and sponsors
Integrate delivery and formulation with downstream bioprocessing and support recovery optimization
Maintain accurate laboratory records and adhere to safety and quality standards