Senior/Lead Bioinformatics Scientist (Multi-Cancer Early Detection)

Natera•San Carlos, CA

2h•$131,000 - $180,000

About The Position

Natera’s Research team is building tests that can detect many cancers from a single blood draw. We are looking for a Senior or Lead Bioinformatics Scientist to join the team building the technology at the heart of that effort. You will work with large-scale, multi-modal genomic datasets from clinical cohorts and partner closely with molecular biologists and clinical scientists. You will help advance the state-of-the-art and drive new methods from prototype, through scalable implementation, toward clinical validation and, ultimately, to patients.

Requirements

Ph.D. in Bioinformatics, Computer Science, Biology, or a related field; alternatively a Bachelor’s or Master’s degree with at least 4 years of professional experience
Track record developing and validating analysis workflows for high-throughput sequencing data
Experience applying and evaluating statistical and ML methods to large datasets
Strong quantitative reasoning and data analysis skills, applied effectively to real scientific problems.
Software development experience, including proficiency in Python and its scientific computing ecosystem
Fluent using Linux command-line tools and cloud computing environments
Strong verbal and written communication skills

Nice To Haves

Working knowledge of DNA methylation and other epigenomic data
Experience with cell-free DNA and liquid biopsy samples
Background in cancer genomics or diagnostics
Experience working with data and metadata from large clinical cohorts
Familiarity using AI tools for complex scientific tasks and with foundation models applied to biological data

Responsibilities

Develop and validate new algorithms to analyze large multimodal epigenomic datasets
Drive research analyses through implementation, testing and performance evaluation, including developing new features within existing pipelines
Work with sequencing and clinical data from large cohorts, ensuring data integrity and quality control
Partner with molecular biologists and clinical scientists to solve challenging, open-ended problems
Visualize results and present complex findings to both technical and non-technical audiences
Contribute to the team’s standards for code quality and reproducibility