Bioinformatics Research Scientist - Center of Excellence for Pediatric Immuno-Oncology

St. Jude Children's Research Hospital•Memphis, TN

5d•Onsite

About The Position

The Center of Excellence in Pediatric Immuno-Oncology (CEPIO) at St. Jude Children's Research Hospital in Memphis, TN is seeking a Bioinformatics Research Scientist to work on the Immuno-Oncology Target Identification via Systems Immunology (iTARGETS) initiative. This position is imbedded in the lab of Hongbo Chi, PhD, chair of the department of Immunology, and will work with an interdisciplinary group of scientists, postdoctoral research associates, and faculty. In this position, the successful candidate will develop innovative solutions for analyzing and visualizing omics data related to immuno-oncology studies. The candidate will work both collaboratively and independently on projects within the CEPIO. The candidate will lead cutting-edge computational analyses of omics datasets including transcriptomics, proteomics, scRNA-seq, ATAC-seq, spatial omics, CRISPR screens, and other datasets, along with filling other needs as they are identified. The candidate will ensure the highly effective and accessible end results of these projects, as well as the scientific rigor and accuracy. St. Jude Children's Research Hospital offers a unique environment with clinical and basic science investigators working in proximity and interacting regularly to translate scientific discoveries into improved therapies for children. CEPIO was established in 2023 and serves as the central hub to advance and coordinate cross-disciplinary studies in immuno-oncology across St. Jude basic and clinical Departments, Cores, and Centers. Focused areas of research include systems immunology, functional genomics, and translational immuno-oncology.

Requirements

Strong programming skills in R and Python with experience developing bioinformatics workflows and data analysis pipelines.
Hands-on experience using Linux operating systems and high-performance computing (HPC) environments for large-scale data processing.
Extensive experience analyzing and interpreting next-generation sequencing (NGS) data, including CRISPR screening, single-cell RNA-seq, ATAC-seq, ChIP-seq, and spatial transcriptomics.
Bachelor's degree in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry) or related field.
Experience in at least one programming or scripting language and at least one statistical package, with R preferred.

Nice To Haves

Master's degree or PhD preferred.

Responsibilities

Independently perform basic and advanced level statistical analysis, algorithm implementation, programming from a variety of biotechnology platforms, and oversee quality check.
Design and prepare materials and courses for training on various bioinformatics software and databases, computing, data mining, and analysis.
Act as a liaison between end-users, software developers, system designers, and different departments.
Establish protocols or best practices for common research tasks and SOP, evaluate products and solutions to make recommendations, and integrate solutions.
Lead the development, implementation, installation, and maintenance of databases; coordinate data collection, database implementation, and usage and any hardware and software related to database collection.
Develop programs to assist in the analysis of data within the databases.
Assist in planning, coordinating, and organizing projects across departments and delegate tasks based on priority, expertise, and capacity.