Bioinformatics Engineer, Oligonucleotide Drug Discovery

LatchBio•San Francisco, CA

21h•$120,000 - $180,000•Remote

About The Position

As molecular data generation and frontier model intelligence grows, new approaches to data analysis are needed across the biotech industry. Latch is building intelligent, high performance agents for biological data analysis, empowering over 5,000 scientists across 150+ R&D labs to handle data from instrument-to-insights. We're seeking a BioEngineer for Oligonucleotide Discovery to join our therapeutics bench, working at the frontier of what artificial intelligence can achieve in biology. You will contribute to our technical approach to teaching agents how to understand and handle complex drug discovery and development data, working across end-end workflows from instrument outputs and experimental readouts to real scientific decisions. You will work as part of a team of software engineers, biologists, and drug hunters building datasets to teach these agents to reason better across: Genetic target and MoA selection, ASO/siRNA drug design, Screening and functional characterization, Pharmacology.

Requirements

3+ years hands-on experience with oligonucleotide (ASO/siRNA), RNA therapeutics, or related.
Experience in drug target validation or mechanism-of-action studies using functional or population genomics.
Familiarity with drug discovery and development workflows — sequence design, knockdown screening, or preclinical PK/PD.
Proficiency in AI agent use.

Responsibilities

Contribute to the technical approach for teaching agents to understand and handle complex drug discovery and development data.
Work across end-to-end workflows from instrument outputs and experimental readouts to real scientific decisions.
Collaborate with software engineers, biologists, and drug hunters to build datasets for AI agents.
Improve AI agent reasoning across genetic target and MoA selection, ASO/siRNA drug design, screening and functional characterization, and pharmacology.