Associate Scientist
About The Position
The Protein Homeostasis Thematic Research Center (TRC) at Bristol Myers Squibb (BMS) is a fundamental Oncology research engine focused on discovering and developing therapeutics for oncology and hematology. The TRC leverages BMS' expertise in protein degradation to target tumor-intrinsic vulnerabilities and resistance mechanisms, aiming to address previously undruggable protein classes. The Pharmacology group within the TRC in San Diego supports discovery teams by providing in vivo pharmacology for small and large molecules in oncology and immune-oncology. This includes supporting lead identification through in vivo model screening and mechanism-of-action studies, developing and validating animal disease models, identifying pathway biomarkers, and establishing clinically relevant endpoints. Collaboration with DMPK, Exploratory Toxicology, and Translational Development is key, and the group contributes preclinical data to inform clinical development plans.
Requirements
- Bachelor's Degree
- 2+ years of academic and / or industry experience
- Excellent interpersonal, communication, presentation, collaboration, and organizational skills
- Detail-oriented, focused, and able to deliver high-quality data efficiently
Nice To Haves
- Bachelor's Degree and 2+ years of experience with oncology models
- Experience in mammalian cell culture
- Experience in the development of syngeneic and xenograft cancer models
- Proficient in animal handling, dosing (PO, IP, IV, and SC), tumor cell inoculation, data collection and analysis
- Hands-on experience in small animal surgeries, necropsy and tissue and blood collection
- Hands-on experience in evaluating small molecules in animal models
- Experience with small animal imaging modalities (e.g., Xenogen, ultrasound etc.) is a plus
- Skilled in Western blots, ELISA, MesoScale, IHC, flow cytometry, RNA/DNA extraction, and PCR
- Proficient in Excel, Word, PowerPoint, FlowJo, GraphPad Prism, and Studylog
Responsibilities
- Develop disease models for oncology and immune-oncology
- Independently design and execute in vivo efficacy and PK/PD experiments to identify drug candidates
- Analyze and interpret data accurately, reporting findings to supervisors and colleagues
- Troubleshoot routine issues and recommend solutions
- Evaluate endpoints from in vivo studies using Western blots, mesoscale, qPCR, IHC, etc.
- Write precise protocols and technical reports
- Present data to multidisciplinary discovery teams
- Collaborate with cross-functional team members
Benefits
- Medical, pharmacy, dental, and vision care
- BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP)
- 401(k) plan
- Short- and long-term disability
- Life insurance
- Accident insurance
- Supplemental health insurance
- Business travel protection
- Personal liability protection
- Identity theft benefit
- Legal support
- Survivor support
- Flexible time off (unlimited, with manager approval)
- 11 paid national holidays
- 160 hours annual paid vacation for new hires with manager approval
- 3 optional holidays
- Unlimited paid sick time
- Up to 2 paid volunteer days per year
- Summer hours flexibility
- Leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs
- Annual Global Shutdown between Christmas and New Years Day
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
