Associate Scientist - Upstream Cell Culture

Novartis • Durham, NC

2d • Onsite

About The Position

The Technical Research & Development (TRD) Department drives the advancement of the Adeno-associated virus (AAV) and Lentiviral vector (LVV) production platform across multiple development sites and manages the development, scale-up, scale-down, transfer, optimization, and characterization of processes for the clinical manufacturing of Novartis cell gene therapy products.

Requirements

• Experience with bioreactor operation including ambr® (15 & 250), bench-top bioreactor, pilot scale bioreactor.
• Proficient in statistical analysis principles and software.
• Working knowledge and experience with Design of Experiment (DoE).
• Ability to analyze data to make date-driven decisions and further progress development strategies.
• Excellent team player with good communication skills.

Nice To Haves

• Knowledge of viral gene therapy and previous experience with AAV process development is preferred.

Responsibilities

• Designs and executes gene therapy upstream process development studies.
• Supports early development study projects and late-stage process characterization and scaling up studies.
• Analyses and interprets experimental data from process studies with strong statistical mindset.
• Conducts laboratory studies to enhance AAV and LVV manufacturing technologies, capabilities, and processes (such as media development, bioreactor fed-batch and perfusion process development, optimization and scale-up).
• Preforms experiments at different scales to support pre-clinical, clinical and commercial programs.
• Assists the evaluation and introduction of new technologies.
• Authors technical reports and presents results of development studies both internally and externally.
• Collaborate with cross-functional groups to coordinate studies.
• Other related duties as assigned.

Benefits

• health, life and disability benefits
• a 401(k) with company contribution and match
• a variety of other benefits
• a generous time off package including vacation, personal days, holidays and other leaves

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level