Associate Scientist - Recombinant Protein Development

Revvity•San Diego, CA

1d•Onsite

About The Position

BioLegend is seeking an Associate Scientist for its Recombinant Protein team. This role focuses on developing functional protein products using advanced protein expression and purification technologies, contributing to business revenue by creating high-quality, sellable research reagents. The individual will design and implement gene-to-protein workflows, optimize protein expression, purification, and characterization across prokaryotic and eukaryotic platforms, and ensure product quality and safety through critical thinking and troubleshooting. The position also involves initiating sustainability efforts for existing designs and offers opportunities for technology exploration, scientific knowledge expansion, leadership development, and career growth. Responsibilities include laboratory-based protein processing (cell lysis, refolding, purification using chromatography) to develop final product formulations, and active collaboration with multidisciplinary teams to ensure timely delivery of orders and projects.

Requirements

B.S. degree with minimum 6 years’ experience in Biotechnology industry
M.S. degree with minimum 3 years’ experience in Biotechnology industry
3+ years of hands-on experience with protein purification via various chromatography methods.

Nice To Haves

PhD degree in Life Sciences or related fields with Biotechnology industry experience with demonstrated quality system knowledge including ISO 13485.
Experience in protein product production including protein expression and purification proteins.
Extensive experience in protein or antibody purification and modification.
Extensive experience in process optimization for production scale up.

Responsibilities

Familiar with recombinant protein product expression platforms of various protein families such as cytokines, growth factors, enzymes, ligand receptors, and recombinant immunogens from different research areas such as carcinogenesis, immunology, neuroscience, etc.
Implement bacterial protein expression culture and develop and run protein purification schemes using various chromatography methods on various platforms (i.e., AKTA FPLC, HPLC).
Follow GDP (Good Document Practices) on processing records and conduct technical transfer under ISO9001:2008/ISO13485:2016 standards.
Participate in product design and developmental stage review.
Provide quality records to ensure traceability and risk control for product releasing.
Own assigned product family in new product development and is responsible for driving projects to their completion.
Support troubleshooting and optimization on protein expression, homogeneity, and stability of developing and released products.
Work with the team and QA to execute and validate different protein processes, equipment and chemistry protocols.
Support to facilitate Manufacturing Group for purification/QC workflow development and SOP optimizing/troubleshooting in various production stages, including expression constructs, culture systems, purification schemes, formulation, and stability issues.
Establish, coordinate, and communicate project timelines and deliverables with internal, and external team to provide weekly, monthly, and quarterly reports.
Responsible for personnel training, goal setting and performance management.
Maintain a current knowledge of protein chemistry, synthetic biology, and scientific literature.
Other project responsibilities may be.