Associate Scientist, Protein Sciences
About The Position
About CytomX Therapeutics: CytomX Therapeutics, Inc. is committed to changing the treatment of cancer with our novel PROBODY® therapeutic platform. Our commitment to transforming lives with safer, more effective therapies is driven by our curiosity and passion for innovation and our belief that by acting with integrity in an honest, respectful, ethical manner, we have the power to change lives. Our workplace embodies collaboration, open communication, celebrating our successes, and holding each other to the highest possible standards. CytomX’s robust and differentiated pipeline comprises therapeutic candidates across multiple treatment modalities including antibody-drug conjugates (“ADCs”), T-cell engagers, and immune modulators such as cytokines. CytomX’s clinical-stage pipeline includes CX-2051 and CX-801. Learn more at www.cytomX.com. Who You Are and What You’ll Do: You are passionate about the life sciences and making a difference for cancer patients, their families, and healthcare providers. You will be responsible for developing protein production and purification strategies to support all discovery PROBODY programs at CytomX, as well as developing analytical methods—including LC-MS—to characterize these novel molecules. Additionally, you will work closely with the Protein Engineering and Research teams to transition therapeutic programs from discovery to clinical development.
Requirements
- PhD in Biochemistry or Protein Chemistry or related discipline OR MS in Biochemistry with 5+ years of experience in the biotechnology or biopharma industry with increasing responsibility
- Expertise in problem solving the protein purification issues is required.
- Expertise in large and small-scale protein purification using AKTA systems, Tecan or Janus liquid handler system is required.
- Expertise in protein characterization assays such as concentration, endotoxin measurement, SDS-PAGE, CE-SDS, SEC-HPLC, RP-HPLC, HIC and IEF are required.
- Hands-on experience in operating HPLC or UPLC instruments is required.
- Experience in developing analytical methods to characterize antibodies, bispecifics and cytokines is required.
- Experience in managing the protein purification workflow is required
- Please note that a presentation of a scientific seminar is required during the interview process
Nice To Haves
- Experience in antibody therapeutics is preferred.
- Expertise in molecular biology techniques such as cloning, sequencing, etc. is desired.
- Hands-on experience in operating various mass spec instruments and associated software for data analysis preferred.
- Expertise in developability assessment of therapeutic biologics molecules is required
Responsibilities
- Develop parallel purification processes for antibodies, bispecifics and cytokines
- Collaborate with discovery, protein engineering and pharmacology to provide therapeutic and reagent proteins of appropriate quality for use in in vitro and in vivo studies.
- Develop production and purification strategies for various PROBODY bispecific formats
- Solving protein purification problems based on scientific principles, current technologies, and personal experience
- Support the lead selection process by developing various analytical, LC-MS and biophysical methods to characterize novel PROBODY molecules.
- Participating in cross-functional discovery supports and effectively communicates information to appropriate groups and protein sciences staff.
Benefits
- A great environment where we work collaboratively, leverage each other’s strengths, and work toward a shared vision with our common goals of doing the best thing for patients.
- A robust and enduring approach to your development and career growth fueled by a strong learning curriculum and career guidance that helps you understand how you can grow your career at CytomX.
- A robust and highly competitive total rewards program that helps you achieve your compensation goals while supporting a great work / life balance.
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
