Associate Scientist I, Formulation Development
About The Position
At Avidity Biosciences, we are passionate about the impact of every employee in realizing our vision of improving people’s lives by delivering a new class of RNA therapeutics. Avidity is revolutionizing the field of RNA with its proprietary AOCs, which are designed to combine the specificity of monoclonal antibodies with the precision of oligonucleotide therapies to address targets and diseases previously unreachable with existing RNA therapies. If you are a committed, solution-oriented thinker, join us in making a difference and become part of our growing culture that is integrated, collaborative, agile and focused on the needs of patients. Avidity Biosciences, Inc.'s mission is to profoundly improve people's lives by delivering a new class of RNA therapeutics - Antibody Oligonucleotide Conjugates (AOCs™). Utilizing its proprietary AOC platform, Avidity demonstrated the first-ever successful targeted delivery of RNA into muscle and is leading the field with clinical development programs for three rare muscle diseases: myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). Avidity is headquartered in San Diego, CA. For more information about our AOC platform, clinical development pipeline, and people, please visit www.aviditybiosciences.com and engage with us on LinkedIn and X.
Requirements
- A bachelor’s degree (or master’s) in chemistry, biology, pharmaceutical sciences, or a related field with a minimum of 5 years of industrial experience (3 years for a master’s degree).
- An understanding of protein physicochemical stability, particularly for common routes of mAb degradation
- Experience in setting up and managing formulation development and in-use compatibility studies.
- Hands-on experience with a variety of analytical methods including SEC, IEX, RP-HPLC, CE-SDS, cIEF and subvisible particle analysis
- Experience using a variety of biophysical methods for characterizing and measuring conformational and colloidal stability of protein biologics including differential scanning calorimetry, dynamic and static light scattering techniques
- Ability to multi-task and work in a fast-paced cross-functional matrix environment
- Demonstrated excellent communication (oral and written), teamwork, organizational, interpersonal, and problem-solving skills
Nice To Haves
- Experience using design of experiment (DOE) approaches
- Familiarity with mass spectrometry (MS) methods used for assessing mAb chemical stability and assessing ADC drug to antibody ratios including intact, reduced, and peptide mapping LC/MS
- Prior experience in lyophilization formulation, cycle development, and analytical testing
- Experience in oligonucleotide chemistry and characterization methods
- Experience working with external CMOs and CROs
Responsibilities
- Work with TD&O team members to set up and conduct formulation stability studies of mAb and AOC liquid and lyophilized dosage forms
- Perform developability assessments of numerous early-stage protein biologics using a variety of predictive analytical and biophysical methods
- Perform routine lab tasks including preparing buffers, managing the inventory of laboratory consumables and supplies, and working with vendors for maintenance and troubleshooting of analytical instruments
- Conduct in-use compatibility studies of AOC drug products intended for intravenous and subcutaneous routes of administration
- Support mAb and AOC drug substance/product process development activities when needed
- Be a hands-on presence in the laboratory and support biology and chemistry departments with analytical and biophysical characterization as needed
- Specify, purchase, and manage the installation of formulation-related instrumentation and equipment
- Maintain good documentation in an electronic notebook and write technical reports as required
- Present data at regular team and cross functional team meetings
- Contributes to the company’s core values (agile, visionary, integrated and diverse)
Benefits
- Annual bonus
- 401(k) with an employer match
- Medical coverage
- Dental coverage
- Vision coverage
- LTD (Long-Term Disability) coverage
- Four weeks of time off
- Learning and development programming
- Job-specific training
- Education reimbursement program
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
