Associate Principal Scientist - Immune Cell Fitness

AstraZeneca • Waltham, MA

1d • Onsite

About The Position

At AstraZeneca, we're embarking on an exciting new frontier in medical science – the quest to extend human health span. Our newly formed Aging Research Group is at the forefront of this groundbreaking initiative, aiming to develop innovative therapeutics that not only add years to life but life to years. We are seeking a highly motivated Associate Principal Scientist to join our newly formed, dynamic team. As a key member of our compact yet growing group, you'll lead efforts to understand the mechanisms underlying the fitness of immune cells. At AstraZeneca, you'll have the opportunity to make a significant impact on the future of healthcare while working in a collaborative environment at the cutting edge of research. The ideal candidate will thrive in this setting, contributing to our growth trajectory as we build our evolving team. AstraZeneca seeks an innovative and highly motivated Associate Principal Scientist with an extensive background in the design, testing, and development of modalities affecting immune cell fitness. As an Associate Principal Scientist, you will be a key member of a team focused on supporting efforts to modulate immune function through the drug discovery process. You will bring your expertise in Immunotherapeutic Development to lead novel drug discovery programs from inception, establish assay systems and deliver datasets that will have direct impact on pipeline programs.

Requirements

• PhD in immunology, biochemistry, and/or immuno-oncology, with at least 1 year of post-doctoral experience.
• Demonstrated background examining the mechanisms of cellular resistance and cellular aging as they apply to immune cell fitness.
• Program leadership experience including the mentoring and managing of junior scientists.
• Mastery of techniques to interrogate immune function, with an emphasis on immunometabolism and cellular fitness/resistance.
• Comprehensive understanding of immune cell lineages, development, and function in homeostatic and diseased states.
• Ability to independently design and execute research plans for one or more programs, and to review, analyze, and interpret experimental results rapidly.
• Ability to draft, execute and record protocols and experiments in a timely manner and maintain an excellent laboratory notebook.
• Job complexity is high and requires the ability to work with high degree of independence as well of a sense of urgency.
• Strong interpersonal, influencing, negotiating and collaboration skills together with evidence of having used these to support problem solving and delivery in a team-oriented, collaborative environment.
• Proven track record of success in your research and experience preparing written scientific reports and oral presentations.

Nice To Haves

• Experience in the generation, analysis, and interpretation of high-dimensional analyses (flow cytometric, bulk and/or scRNA seq) is a strong advantage.

Responsibilities

• Lead efforts to understand the mechanisms underlying the fitness of immune cells.
• Lead novel drug discovery programs from inception.
• Establish assay systems and deliver datasets that will have direct impact on pipeline programs.
• Design, test, and develop modalities affecting immune cell fitness.
• Support efforts to modulate immune function through the drug discovery process.
• Mentor and manage junior scientists.

Benefits

• Eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles.
• Qualified retirement programs
• Paid time off (i.e., vacation, holiday, and leaves)
• Health, dental, and vision coverage

What This Job Offers

• Job Type: Full-time
• Career Level: Principal
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees