Associate Director, Operational Excellence

Tango Therapeutics•Boston, MA

About The Position

The Operational Excellence and Training Lead enables scalable, efficient, and inspection-ready execution across Development by designing standardized processes, building operational capabilities through training, and driving consistent adoption and continuous improvement. The role owns the end-to-end design, implementation, and optimization of assigned processes and systems, translating strategic objectives into fit-for-purpose standards that are efficient, scalable, and inspection-ready. The position defines process standards, guidance, roles, accountability, and performance measures; designs and delivers process and role-based training; and maintains curricula, including onboarding. It identifies inefficiencies, risks, and variability through data analysis and stakeholder input, then leads targeted improvement initiatives. The role supports process adoption through change management, training, and practical guidance, while ensuring processes are documented, consistently applied, and auditable. The Associate Director tracks and reports process performance, improvement outcomes, and residual risks to Operational Excellence and Clinical Compliance leadership. As a subject-matter expert and trusted advisor, the role supports functional teams and leadership in operational rigor, learning strategy, capability building, and fostering a culture of accountability, consistency, and continuous improvement. Tango Therapeutics is a biotechnology company focused on discovering novel drug targets and developing precision medicines for cancer. Its labs and offices are located in Boston, Massachusetts.

Requirements

Bachelor’s degree in Life Sciences or a related field.
8–10+ years of experience in operational excellence, process improvement, training, or operational leadership within a regulated life sciences or clinical development environment.
Proven experience owning and implementing end-to-end processes or systems across multiple functions.
Hands-on experience designing and delivering process and role-based training.
Experience supporting audit and inspection readiness, including documentation and behavioral readiness.
Knowledge of end-to-end process design, standardization, and optimization.
Knowledge of Lean or continuous improvement methodologies.
Knowledge of training design, curriculum development, and adult learning principles.
Experience with process documentation, including SOPs, guidance, and work instructions.
Knowledge of process performance metrics, KPIs, and dashboarding.
Understanding of compliance and inspection expectations in regulated environments.
Strong systems thinking and ability to translate strategy into execution.
Excellent facilitation, communication, and stakeholder-engagement skills.
Ability to influence and drive adoption without direct authority.
Pragmatic change leadership and strong execution discipline.
Trusted-advisor mindset with high credibility and accountability.
Collaborative, service-oriented, and improvement-focused approach.

Nice To Haves

Advanced degree, such as an MBA or MSc.
Certification or formal training in Operational Excellence, Lean, Six Sigma, or Process Improvement.

Responsibilities

Own and lead the end-to-end design, implementation, and optimization of assigned processes and systems across Development.
Translate strategic objectives into fit-for-purpose, standardized, efficient, scalable, and inspection-ready processes.
Define process standards, guidance, performance measures, roles, and accountability.
Develop and deliver training on new or changed processes, including compliance expectations and inspection-readiness behaviors.
Design and maintain role-based and process-based curricula, including onboarding.
Identify inefficiencies, risks, and variability using data analysis and stakeholder input, and lead targeted improvement initiatives.
Support functions in adopting new or improved processes through change management, training inputs, and practical guidance.
Ensure processes are well documented, consistently applied, and auditable to support inspection readiness.
Track and report process performance, improvement outcomes, and residual risks to Operational Excellence and Clinical Compliance leadership.
Act as a subject-matter expert and trusted advisor to functional teams on process excellence and operational rigor.
Support leadership in defining and executing the learning and capability-building strategy for Development functions.
Support leadership in building a learning culture that reinforces accountability, consistency, and continuous improvement.