Associate Director of RWD Engineering

Lilly • Indianapolis, IN

4d • $156,000 - $228,800 • Hybrid

About The Position

The RWD Data Engineering role supports the end-to-end engineering vision for Lilly’s real-world data (RWD) infrastructure. This role involves designing and executing scalable, cloud-native pipelines and data products that enable various teams (HEOR, SDIA, Statisticians, Medical, Clinical) to generate evidence more efficiently and with greater scientific depth. The position requires a deep understanding of the multi-modal RWD ecosystem across Lilly’s therapeutic areas to contextualize and drive RWD to necessary end-user data products. Responsibilities include supporting the creation of sophisticated data engineering products, automating data ingestion and product creation processes, and leading special projects for Global Medical Affairs – Health Economics and Outcomes functions and the broader enterprise. The role also involves identifying and advocating for standard processes across the data asset lifecycle, collaborating closely with other data domain and analytics leaders, and leading the technical implementation of data products, ensuring scalability, reliability, and performance. The ideal candidate will have deep expertise in data engineering, strong problem-solving skills, and a passion for leveraging data to drive business outcomes. This position works with the Sr. Director – RWD Architecture – Engineering and reports to the Director – RW Data Engineering, embedded within the BIA organization and in close partnership with HEOR, SDIA, Statisticians, Medical, and Clinical teams.

Requirements

• Bachelor’s degree in Computer Science, Engineering, Statistics, Information Technology, Bioinformatics, or Technical Field.
• Minimum of 3 years of hands-on data engineering experience with a demonstrated focus on healthcare or life sciences RWD.
• Minimum of 3 of applied expertise across Python, SQLJava, Spring, Spring Boot, Prefect, and/or other business intelligence tools, , ETL/ELT pipelines, and cloud platforms (AWS Glue/EMR, Snowflake, or Databricks), — applied directly to real-world healthcare data at scale.
• High proficiency in SQL optimization across cloud platforms — complex joins, window functions, query tuning, workload management — on AWS Redshift, Databricks SQL, Snowflake, or BigQuery.
• Python fluency: pandas, PySpark, Polars for large-scale data manipulation; workflow orchestration with Apache Airflow, Prefect, or Dagster for production pipeline scheduling and monitoring — including Databricks Workflows for orchestrating multi-task jobs within the Lakehouse.
• Distributed computing: Apache Spark (PySpark), Dask, or Ray — ability to write, tune, and debug distributed jobs processing multi-terabyte datasets across partitioned cloud storage, including Databricks clusters with auto-scaling and spot instance optimization.
• Cloud data engineering: hands-on pipeline development on AWS (S3, Glue, Redshift, EMR), Azure (ADLS, Synapse, ADF), or GCP (BigQuery, Dataflow) — as well as Databricks on any major cloud (AWS, Azure, or GCP) using Unity Catalog for cross-workspace governance — not just configuration.
• Delta Lake / Apache Iceberg: time travel, schema evolution, upsert/merge operations, partition optimization — building versioned, ACID-compliant data assets at scale; Delta Lake experience ideally hands-on within the Databricks Lakehouse platform using Delta Live Tables (DLT) for declarative pipeline authoring.
• ETL/ELT tooling: AWS Glue, dbt, dbt-databricks, or equivalent for building tested, documented transformation pipelines with automated data quality checks; familiarity with Databricks Asset Bundles (DABs) for packaging and deploying notebooks, jobs, and DLT pipelines as code.
• DevOps fluency: Git, CI/CD pipelines (GitHub Actions, Azure DevOps), Docker — maintaining all pipeline code as version-controlled, testable, and deployable artifacts; experience deploying to Databricks via CLI, REST API, or Terraform provider a plus.
• Strong fluency with data modeling: designing star/snowflake schemas, OMOP-compliant structures, and flat domain long files optimized for analytical workloads in a research context — including materializing these structures as managed Delta tables within Databricks Unity Catalog with appropriate access controls and lineage tracking.
• Medical and pharmacy claims: deep working knowledge of CCAE, Optum Clinformatics, IQVIA PharMetrics, Truveta, and Komodo data structures — enrollment/eligibility tables, revenue codes, place-of-service codes, inpatient vs. outpatient claim splitting, drug identification at NDC and GPI level, and known structural quirks of each source.
• Complex EHR data: HL7 FHIR resources, Epic/Cerner/Truveta data models, clinical note schemas, problem list hierarchies, medication order and administration tables, lab result normalization, and vital sign time series — including semi-structured and nested JSON/XML from EHR exports and FHIR APIs.
• Healthcare terminology and ontology mapping: ICD-10-CM/PCS, ICD-9-CM, NDC, RxNorm, SNOMED CT, CPT-4, HCPCS, LOINC, ATC — building, versioning, and governing code list repositories joined to raw tables to produce concept-labeled analysis-ready datasets.
• OMOP CDM: transforming source claims and EHR data to OMOP v5.x including vocabulary loading (Athena), ETL specification documentation, and Achilles/DQD data quality checks.
• Phenotyping and cohort construction: translating clinical study protocols into reproducible extraction logic — index date derivation, washout periods, time-varying covariates, censoring — suitable for pharmacoepidemiology and HEOR studies.
• Regulatory and privacy frameworks: HIPAA-compliant data handling, de-identification standards (Safe Harbor, Expert Determination), DUA compliance, and audit trail requirements for FDA-grade RWE submissions.
• Deploy NLP pipelines for structured extraction from unstructured clinical notes — operationalizing pre-trained biomedical language models (BioBERT, ClinicalBERT) for outcome ascertainment and phenotyping within the data pipeline.
• Implement AI-powered data profiling and anomaly detection to automate quality checks across large ingestion runs and surface issues before they reach analytical teams.
• Use LLM-assisted SQL generation and code review tools to accelerate pipeline development and reduce query errors at scale.
• Apply intelligent caching, query result reuse, and automated feature engineering to optimize compute costs and prepare multi-modal variables for downstream ML inputs.
• Familiarity with MLOps tooling (MLflow, SageMaker, Azure ML) for versioning and monitoring AI models integrated with data pipelines.
• Strong problem-solving skills, attention to detail, and ability to work effectively in matrixed, cross-functional teams with both technical and scientific partners.
• Demonstrated ability to build production-grade ingestion pipelines for multi-terabyte, multi-modal datasets: claims, complex her..
• Advanced SQL optimization skills for AWS Redshift and/or S3/Databricks-based architectures, including query tuning and workload management.
• Experience with OMOP CDM transformation, vocabulary management (Athena), and federated analytics networks (OHDSI, PCORnet, Sentinel).
• Familiarity with data pipeline observability and quality tooling (dbt, Great Expectations, Monte Carlo).
• Familiarity with FDA RWE Framework guidance, EMA RWD guidance, and audit-readiness requirements for observational studies.

Nice To Haves

• Master’s degree in Computer Science, Engineering, Statistics, Information Technology, Bioinformatics.
• Experience with distributed computing frameworks (Spark, Dask) for large-scale RWD processing.
• Deep understanding of healthcare coding standards (ICD-10, NDC, RxNorm, SNOMED CT, CPT, LOINC), real-world data structures, and major RWD vendors and platforms (Truveta, Optum, IQVIA, Komodo, HealthVerity).
• Familiarity with DevOps and CI/CD practices relevant to data pipeline development and deployment.
• R fluency for collaboration with statistical and HEOR teams on dataset validation and specification.
• Familiarity with bioinformatics workflow managers (Snakemake, Nextflow, WDL) and genomics cloud platforms (DNAnexus, Terra, AWS Genomics CLI).
• Knowledge of Agile/Scrum methodologies and project management tools such as JIRA
• Knowledge and experience with –omics RWD: Genomics (e.g., ingesting and processing VCF/GVCF files, PLINK binary formats (bed/bim/fam), Transcriptomics (e.g., bulk RNA-seq count matrices (featureCounts, STAR/RSEM), single-cell and single-nucleus RNA-seq (AnnData/h5ad, 10x Genomics CellRanger) — ingestion, normalization, and linkage to clinical phenotype data; Proteomics (e.g., DIA/DDA mass spectrometry output (MaxQuant, DIA-NN) and OLINK).
• Recruitment open across sectors: pharma/biotech data teams, RWD vendors (Truveta, Komodo, Optum, IQVIA, HealthVerity), cloud providers (AWS, Google, Microsoft), genomics platforms (Illumina, DNAnexus, Broad Institute), or academic health systems with large-scale RWD programs.

Responsibilities

• Lead the design, development, and implementation of cloud-native data products and high-throughput data pipelines that transform raw real-world data into scalable, reliable, analysis-ready assets supporting analytics, reporting, and evidence generation.
• Lead the Analytic Data Products Strategy to deliver key data assets that enable streamlined, compliant execution and analytics.
• Own the end-to-end lifecycle of RWD data products, from requirements gathering and prototyping through production deployment and optimization, ensuring scalability, reliability, performance, and reproducibility across cloud environments (e.g., Databricks, AWS S3, Azure Data Lake).
• Build, optimize, and maintain ETL/ELT ingestion and transformation pipelines for large-scale, multi-modal RWD — including claims, complex EHR data, and other linked healthcare datasets — handling data volumes ranging from tens of millions to billions of records.
• Implement and manage lakehouse-style data architectures (e.g., medallion bronze/silver/gold patterns) using Databricks and cloud object storage (AWS S3, ADLS) to produce versioned, partitioned, and audit-ready data assets.
• Write and maintain reusable, version-controlled transformation logic incorporating healthcare coding and terminology standards (e.g., ICD-10/ICD-9, NDC, RxNorm, SNOMED, CPT/HCPCS, LOINC) to produce domain-level datasets such as demographics, diagnoses, treatments, procedures, encounters, and labs.
• Optimize SQL and distributed processing workloads (e.g., Spark-based jobs) for performance across very large datasets, applying partitioning, indexing, predicate pushdown, denormalization, and other optimization strategies appropriate to analytical workloads.
• Translate analytic, business, and research requirements into reproducible data extraction and transformation logic, supporting cohort construction, temporal logic, and consistent reuse of RWD across teams.
• Apply deep understanding of healthcare data structures and standards when engineering data products, ensuring datasets are fit for purpose for downstream analytics and compliant with scientific, regulatory, and audit expectations.
• Establish and implement standard engineering practices and methodology across the data asset lifecycle, including automated data ingestion, data quality checks, integrity testing, validation, monitoring, alerting, and documentation from source table to analysis-ready output.
• Contribute to CI/CD pipeline setup, code review, and testing standards, ensuring all transformation code is version-controlled, tested, and deployable in a reproducible manner.
• Collaborate closely with multi-functional partners — data scientists, statisticians, analytics leaders, and other technical teams — to understand business and technical requirements and develop documentation of RWD engineering standards, transformation templates, code list repositories, and pipeline performance guidelines.
• Provide technical consultation to collaborators on appropriate use of data products and underlying RWD assets, including structural limitations of specific data sources, join strategies, and performance considerations; collaborate with the RWD Operations Lead to develop source-specific training materials for HEOR scientists, SDIA, and statisticians.
• Create an inclusive culture where producing and maintaining high-quality data is a core discipline.

Benefits

• company bonus (depending, in part, on company and individual performance)
• company-sponsored 401(k)
• pension
• vacation benefits
• medical, dental, vision and prescription drug benefits
• flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
• life insurance and death benefits
• certain time off and leave of absence benefits
• well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)
• Relocation assistance is available for qualified candidates.

What This Job Offers

• Job Type: Full-time
• Career Level: Manager