Associate Director, FP&A

Crescent Biopharma • Waltham, MA

1d • Onsite

About The Position

Crescent Biopharma is building a world-leading oncology company focused on bringing new therapies to cancer patients, with a clinical-stage pipeline including a PD-1 x VEGF bispecific antibody and novel antibody-drug conjugates. The company aims to rapidly advance transformative therapies for solid tumors. They are seeking an Associate Director of FP&A to support corporate and program-level planning, budgeting, and forecasting. This role involves partnering with R&D, Program Management, Clinical, Tech Ops, and G&A teams to provide financial insights, support decision-making, and ensure disciplined financial management in a dynamic, science-driven environment. The ideal candidate thrives in high-growth biotech, can balance strategic thinking with hands-on execution, and is eager to build scalable FP&A processes. The position requires the individual to be local to the Waltham, MA office and have experience in the life sciences, biotech FP&A space.

Requirements

• Bachelor’s degree in Finance, Accounting, Economics, or related field
• 8+ years of progressive FP&A experience within biotech or pharma space
• Experience supporting R&D, clinical development, or other multiprogram environments
• Demonstrated ability to partner cross-functionally and communicate complex concepts clearly
• Ability to manage competing priorities and operate in a fast-paced, high-growth environment
• Highly analytical with strong attention to detail
• Proactive problem solver who anticipates needs
• Strong interpersonal skills and business judgment
• Collaborative team player
• Must be local to the Waltham, MA office and have experience in the life sciences, biotech FP&A-space

Nice To Haves

• Experience with biotech planning cycles (e.g., program budgeting, CRO/CMO forecasting) preferred
• Familiarity with ERP systems, planning tools, and business intelligence platforms (e.g., NetSuite, Adaptive Insights a plus)

Responsibilities

• Own the FP&A function across the full early-stage oncology portfolio, spanning discovery research, preclinical development, IND-enabling programs, and Phase I/II clinical trials
• Serve as a strategic finance partner to the Chief Scientific Officer, Head of Clinical Development, and SVP of Tech Ops, providing financial insight and decision support tied to asset progression and portfolio prioritization
• Lead program-level and portfolio-level financial modeling, including cost-to-complete analyses, risk-adjusted NPV assessments, and scenario planning around key preclinical and early clinical inflection points such as IND filings, RP2D determinations, and preliminary efficacy signals
• Oversee financial management of CDMO and CRO relationships supporting IND-enabling toxicology, drug substance/drug product manufacturing scale-up, and Phase I/II clinical execution, including governance of budgets, change orders, and milestone payment schedules
• Drive the annual operating budget, mid-year reforecast and multi-year long-range plan, working cross-functionally with research, CMC, translational medicine, regulatory, and clinical teams to align financial projections with program timelines and go/no-go criteria
• Develop and maintain capital runway models and cash burn analyses to support treasury planning, board reporting, and investor communications at a stage where capital efficiency is critical
• Build and refine FP&A infrastructure including forecasting tools, program tracking systems, and reporting cadences suited to the pace and uncertainty of early-stage drug development
• Present financial results, program spend analyses, and strategic scenarios to the leadership team
• Partner with accounting colleagues to build financial discipline and cross-functional partnership skills appropriate for a fast-moving early-stage biotech environment
• Support business development activities including in-licensing diligence, sponsored research agreement structuring, and collaboration deal modeling focused on early-stage oncology assets

Benefits

• Opportunity to join a mission-driven team where you'll contribute to impactful work, take on varied responsibilities, and grow quickly in a dynamic environment
• Competitive compensation, including base salary, performance bonus, and equity
• 100% employer-paid benefits package
• Flexible PTO
• Two, one-week company-wide shutdowns each year
• A commitment to your professional development, with access to resources, mentorship, and growth opportunities
• Medical
• Dental
• Vision
• Life insurance
• Short- and long-term disability
• Company’s savings plan (401(k))
• Long-term incentive program
• Vacation – Unlimited PTO
• Sick time – 10 days per calendar year
• Holiday pay, including two Company shut downs
• Parental Leave – 16 weeks within one year of the birth/adoption/foster care of a child
• FMLA
• Military Leave

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Number of Employees: 1-10 employees