Associate Director, Clinical Scientist – Neuroimmunology
About The Position
AstraZeneca is seeking an Associate Director, Clinical Scientist, Neuroimmunology to support their neuroimmunology portfolio, starting with multiple sclerosis and expanding to other immune-mediated indications and modalities. This role is for a scientist passionate about clinical drug development and with a strong scientific foundation, who wants to learn the craft of clinical science on breakthrough cell and immunotherapies for immune-mediated neurological disease. The ideal candidate will possess sharp analytical instincts, a search-and-find mindset in complex clinical data, and a collaborative temperament to thrive in a cross-functional team. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company dedicated to discovering, developing, and commercializing prescription medicines for serious diseases. The Neuroimmunology team within Immunology R&D is focused on accelerating the delivery of transformative cell therapies and immunotherapies for patients with immune-mediated neurological disease. AstraZeneca fosters a culture of courage, curiosity, and collaboration, with decisions driven by patient outcomes.
Requirements
- Master's degree in a life-sciences or related field with a minimum of 2 years of relevant clinical or scientific research experience, OR an advanced degree (e.g., PhD, PharmD, MD, MPH, MSN/RN, or equivalent) in a life-sciences or related field.
- Understanding of clinical-trial design, statistical concepts, and the connection between nonclinical and clinical data.
- Familiarity with ICH, GCP, and relevant regulatory requirements.
- Strong analytical skills and a genuine curiosity for patterns in complex clinical data, with meticulous attention to detail.
- Ability to work collaboratively in a fast-paced matrix environment.
- Ability to follow complex direction reliably.
- Sound judgment in handling confidential, regulated information.
- High ethical standards.
- Initiative.
- A collaborative, trustworthy team orientation.
Nice To Haves
- Industry clinical-development experience is a plus but not required at this level.
- Experience in, or strong interest in, cellular therapies, CAR-T, and/or T-cell-engager trials.
- Experience in neurology, multiple sclerosis, or other immune-mediated disease.
- Experience with Phase 1 and Phase 2 clinical trials.
- Data-analysis and programming familiarity (e.g., R, SAS, Python).
- Familiarity with clinical-review tools (e.g., Medidata Rave, J-Review).
- Ability to travel nationally and internationally as needed.
Responsibilities
- Provide clinical-scientific support to monitor, track, and analyze participant data throughout the study lifecycle.
- Contribute to the documents and day-to-day clinical-science work to ensure studies are inspection-ready and decision-enabling.
- Collaborate with Clinical Operations, Data Management, Biostatistics, Clinical Pharmacology (DMPK), Pharmacovigilance, Translational Medicine, and Regulatory.
- Review, track, and analyze clinical-trial participant data, including patient profiles, data listings, summary tables, laboratory and safety parameters, and coded terms for consistency and completeness.
- Contribute to the interpretation of emerging clinical data, identifying clinically meaningful findings, trends, and questions for further evaluation.
- Assist with routine safety and efficacy data review, flagging events of interest or data trends, and preparing preliminary summaries.
- Contribute to query generation, coding reconciliation (AE/SAE, medical/surgical history, concomitant medications), and edit-check refinement.
- Support database-lock readiness activities and cross-checks.
- Contribute to authoring and review of clinical documents such as protocols, amendments, clarification letters, IBs, ICFs, CRFs, eCRF completion guidelines, medical monitoring plans, charters, lab and pharmacy manuals, and training materials.
- Help translate protocol intent into operational deliverables and support the maintenance of the protocol clarification log.
- Contribute to the preparation and review of safety narratives, regulatory-submission sections, responses to health-authority requests, and materials for safety review committees (SRC, IDMC, DMC).
- Support the operational integrity of MS assessments, including central MRI charter adherence, EDSS scoring quality and rater reliability, and relapse-adjudication package completeness.
- Perform analyses and generate scientific slide decks based on clinical, translational, and other datasets.
- Communicate clear overviews of trial data.
- Review and synthesize scientific literature and competitive intelligence to support study and program strategy.
- Contribute to abstracts, posters, manuscripts, and conference materials.
- Support the review of statistical analysis plans and table, listing, and figure shells for traceability.
- Serve as a supporting point of contact for routine scientific and procedural questions from sites and CROs.
- Draft clarifications for team review and support site initiation visits and investigator meetings.
- Assist with deviation trending and CAPAs in partnership with Clinical Operations and vendors.
- Document rationale and escalate clinical-impact items appropriately.
- Maintain up-to-date knowledge of relevant science, GCP, and regulatory guidance.
Benefits
- Eligibility for various incentives
- Opportunity to receive short-term incentive bonuses
- Equity-based awards for salaried roles
- Qualified retirement programs
- Paid time off (vacation, holiday, and leaves)
- Health coverage
- Dental coverage
- Vision coverage
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What This Job Offers
Job Type
Full-time
Career Level
Senior
