Associate Director, Clinical Scientist – Neuroimmunology
About The Position
AstraZeneca is seeking an Associate Director, Clinical Scientist, Neuroimmunology to support their neuroimmunology portfolio, starting with multiple sclerosis and expanding to other immune-mediated indications and modalities. This role is ideal for a scientist passionate about clinical drug development, with a strong scientific foundation and a desire to learn clinical science on breakthrough cell and immunotherapies for immune-mediated neurological diseases. The ideal candidate possesses sharp analytical instincts, a meticulous approach to complex clinical data, and a collaborative spirit to thrive in a cross-functional team. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company dedicated to discovering, developing, and commercializing prescription medicines for serious diseases. The Neuroimmunology team within Immunology R&D is focused on accelerating the delivery of transformative cell therapies and immunotherapies for patients with immune-mediated neurological disease. AstraZeneca fosters a culture of courage, curiosity, and collaboration, making bold decisions driven by patient outcomes.
Requirements
- Master's degree in a life-sciences or related field with a minimum of 2 years of relevant clinical or scientific research experience, OR an advanced degree (e.g., PhD, PharmD, MD, MPH, MSN/RN, or equivalent) in a life-sciences or related field.
- Understanding of clinical-trial design, statistical concepts, and the connection between nonclinical and clinical data.
- Familiarity with ICH, GCP, and relevant regulatory requirements.
- Strong analytical skills and a genuine curiosity for patterns in complex clinical data, with meticulous attention to detail.
- Ability to work collaboratively in a fast-paced matrix environment.
- Ability to follow complex direction reliably.
- Sound judgment in handling confidential, regulated information.
- High ethical standards, initiative, and a collaborative, trustworthy team orientation.
Nice To Haves
- Industry clinical-development experience is a plus but not required at this level.
- Experience in, or strong interest in, cellular therapies, CAR-T, and/or T-cell-engager trials.
- Experience in neurology, multiple sclerosis, or other immune-mediated disease.
- Experience with Phase 1 and Phase 2 clinical trials.
- Data-analysis and programming familiarity (e.g., R, SAS, Python).
- Familiarity with clinical-review tools (e.g., Medidata Rave, J-Review).
- Ability to travel nationally and internationally as needed.
Responsibilities
- Provide clinical-scientific support to monitor, track, and analyze participant data throughout the study lifecycle.
- Contribute to the interpretation of emerging clinical data, identifying clinically meaningful findings, trends, and questions for further evaluation.
- Assist with routine safety and efficacy data review, flagging events of interest and preparing preliminary summaries.
- Contribute to query generation, coding reconciliation, and edit-check refinement in collaboration with Data Management and Biostatistics.
- Support database-lock readiness activities and cross-checks.
- Contribute to authoring and review of clinical documents such as protocols, amendments, IBs, ICFs, CRFs, medical monitoring plans, and training materials.
- Help translate protocol intent into operational deliverables and support the maintenance of the protocol clarification log.
- Contribute to the preparation and review of safety narratives, regulatory submission sections, and materials for safety review committees.
- Support the operational integrity of MS assessments, including MRI charter adherence, EDSS scoring quality, and relapse-adjudication.
- Perform analyses and generate scientific slide decks based on clinical, translational, and other datasets.
- Review and synthesize scientific literature and competitive intelligence to support study and program strategy.
- Contribute to abstracts, posters, manuscripts, and conference materials.
- Support the review of statistical analysis plans and table, listing, and figure shells.
- Serve as a supporting point of contact for routine scientific and procedural questions from sites and CROs.
- Assist with deviation trending and CAPAs in partnership with Clinical Operations and vendors.
- Maintain up-to-date knowledge of relevant science, GCP, and regulatory guidance.
Benefits
- Eligibility for various incentives
- Opportunity to receive short-term incentive bonuses
- Equity-based awards for salaried roles
- Qualified retirement programs
- Paid time off (vacation, holiday, and leaves)
- Health coverage
- Dental coverage
- Vision coverage
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What This Job Offers
Job Type
Full-time
Career Level
Senior
