Associate Director, Bioconjugation

Sutro Biopharma•South San Francisco, CA

1d•Onsite

About The Position

Sutro Biopharma is seeking an innovative and highly motivated Associate Director to join the Protein Biochemistry Group. The successful candidate will serve as a scientific leader in bioconjugation and analytical characterization of conjugates, supporting the discovery and development of next-generation of antibody-drug conjugates (ADCs). This role will be responsible for driving the development, optimization, and implementation of conjugation technologies and analytical workflows, including mass spectrometry-based characterization of proteins and bioconjugates. The Associate Director will be a member of cross-functional efforts to design, characterize, and advance novel conjugates, and contribute to strategic decisions that impact pipeline and platform development.

Requirements

Ph.D. in biochemistry or a related discipline with 8+ years of industry experience
Experience developing and troubleshooting bioconjugation methods is required.
Proficiency in analytical methods for characterization of proteins and bioconjugates utilizing HPLC (SEC, HIC, RP, and IEX), UV-Vis, DLS, SDS-PAGE, CE, and complementary biophysical techniques.
Familiarity with various research-scale affinity methods for protein purification, including desalting, SEC, IMAC, protein A, protein G.

Nice To Haves

Experience working with ADCs or antibody fragments is preferred.
Experience with TFF is a plus.
Experience with recombinant protein expression in E. coli and/or cell-free protein synthesis systems is a plus.

Responsibilities

Lead the conjugation team responsible for the development and optimization of site-specific bioconjugation of next-generation ADCs.
Conjugate and characterize ADCs to support the early-stage research pipeline.
Develop analytical strategies to interrogate conjugation efficiency and biophysical properties of ADCs.
Coordinate with cross-functional teams to drive innovation in conjugation chemistry and evaluate emerging technologies to enhance Sutro's therapeutic platforms.
Collaborate with teams in research and tech ops groups to progress molecules from early leads to early development.