Analytical Scientist I

Prolific Machines•Emeryville, CA

4d•$120,000 - $140,000•Onsite

About The Position

The Analytical Science team is looking for a talented scientist to collaboratively work with our R&D and Bioprocess teams to quantify and characterize broad classes of therapeutic proteins. A successful candidate will bring an outcome-oriented skillset to recombinant protein quantification and characterization. You will work collaboratively with our teams to produce and purify diverse proteins from cell culture processes and be comfortable conducting a wide range of protein quality assessments.

Requirements

PhD in Analytical Chemistry, Molecular Biology, Biochemistry, Pharmaceutical Sciences, with 1+ years of biologics industry experience. Candidates without a PhD but with similar industry experience are encouraged to apply.
Illustrated experience in therapeutic protein characterization approaches (eg. HPLC, SDS, CE, cIEF, LC-MS).
Illustrated the ability to develop, execute, and interpret intact mass, sequence confirmation, and PTM analysis (e.g., glycosylation, disulfide mapping, peptide mapping) through mass spectrometry.
Illustrated the ability to develop, execute, and interpret aggregation and charge variant characterizations for biologics.
Experience in the development and execution of GLP-compliant methods characterizing protein quality attributes across a wide range of therapeutic classes.
Hands-on experience operating LC-MS.
Highly motivated to deliver successful outcomes for internal and external clients.
Excited to work with internal and external clients to deliver project excellence.
Strong communication skills and are comfortable teaching and sharing knowledge at multiple levels of technical detail.

Nice To Haves

Experience with Agilent QTOF instrumentation applied to assay protein quality is a plus, including familiarity with proteomic software.

Responsibilities

Collaborate with cell line development and bioprocess teams for delivery of key internal technology programs and external customer projects.
Develop, optimize, and validate assays for protein titer and quality for broad classes of recombinant therapeutic proteins.
Plan and execute experimentation to understand protein quality through cell line, upstream and downstream process development.
Execute, summarize, interpret, and present routine and complex therapeutic protein characterizations.
Qualify and validate analytical procedures to compliance standards, upholding rigorous standards for execution and documentation.
Routinely operate, maintain, and troubleshoot analytical instrumentation (HPLCs, FPLCs, mass spectrometers).
Author, review, and implement methods, protocols, validations, and standard operating procedures. Ensure processes are followed in accordance with these standards.