Analytical Methods and Instrumentation Scientist

University of Washington Medical Center•Seattle, WA

1d•$90,000 - $108,000•Onsite

About The Position

The Analytical Methods and Instrumentation Scientist (Research Scientist/Engineer 3) will play a critical role in strengthening IPD’s analytical and purification capabilities. By developing reliable, general‑use methods for small‑molecule analysis, enzyme characterization, and chromatography workflows, this position directly supports a wide range of protein design and enzyme engineering projects. In addition to method development and data analysis, the RS3 provides extensive training for graduate students, postdocs, and other researchers across core instrumentation such as FPLC, HPLC, LC‑MS, and SPR systems. This work ensures that IPD scientists can generate high‑quality and reproducible data and builds long‑term technical capacity essential to IPD’s mission to design proteins that address global challenges.

Requirements

Bachelor's degree in Biochemistry, Biology, Physics or related field and four years of experience with small‑molecule analytical techniques
Hands‑on experience with small‑molecule analytical techniques, including method development, optimization, and validation across diverse analytes.
Proficiency with U/HPLC (Agilent) systems, including routine maintenance, troubleshooting, and advanced method setup.
Experience operating and supporting LC‑MS (Agilent) instruments, including data acquisition, analysis, and interpretation.
Strong understanding of chromatography principles and purification strategies using FPLC systems such as ÄKTA.
Familiarity with SPR (Cytiva) instrumentation and associated analytical workflows.
Demonstrated ability to develop general‑use protocols, SOPs, and reference datasets that improve reproducibility and accessibility for trainees.
Proven experience mentoring and training trainees, including graduate students, postdoctoral fellows, and staff, in analytical techniques and instrumentation use.
Strong scientific and technical problem‑solving skills, including diagnosing mechanical, fluidic, electronic, and software issues across multiple instrument platforms and working with technical support to request service visits as needed.
Ability to manage multiple analytical projects simultaneously while maintaining high standards of data quality and instrument reliability.

Nice To Haves

Doctorate degree in chemistry, biochemistry, chemical engineering, or a related field.
4 years of relevant experience in analytical chemistry or instrumentation support.
Experience developing and optimizing small‑molecule analytical methods, including complex assay design and validation.
Familiarity with managing and maintaining analytical instrumentation such as FPLC, HPLC, LC‑MS, and SPR systems.
Experience with protein expression and purification workflows that interface with chromatography and analytical characterization.
Strong understanding of analytical chemistry and biophysical principles and their application to protein design, enzyme engineering, and small‑molecule characterization.
Experience contributing to grant proposals or securing funding for scientific or instrumentation‑related projects.
Ability to contribute to high‑quality scientific publications and present analytical findings to multidisciplinary research teams.
Experience implementing or improving automated or high‑throughput analytical workflows.
Familiarity with data processing environments and software used for large‑scale analytical datasets, including command‑line tools and scripting for data analysis.

Responsibilities

Train and mentor graduate students, postdoctoral fellows, and other research staff in FPLC (AKTA), U/HPLC (Agilent), LC‑MS (Agilent), SPR (Cytiva), and related analytical techniques.
Develop and maintain standard operating procedures for instrument operation, preventative maintenance, method execution, troubleshooting, and data analysis.
Provide ongoing scientific and technical guidance to help trainees build long‑term competency in analytical workflows and instrument care.
Develop, optimize, and validate analytical and purification methods for small molecule analysis, enzyme characterization, and chromatography workflows using FPLC (AKTA), U/HPLC (Agilent), LC‑MS (Agilent), SPR (Cytiva), and related analytical systems.
Perform data analysis to improve sensitivity, reproducibility, and throughput across IPD analytical pipelines.
Create general‑use protocols and reference datasets that support consistent and reproducible use of core instrumentation.
Collaborate with researchers to refine methods that support small molecule, protein and enzyme design and contribute to the interpretation of analytical results.
Manage and maintain IPD instrumentation including FPLC (AKTA), U/HPLC (Agilent), LC‑MS (Agilent), SPR (Cytiva), and related analytical systems and other core analytical equipment.
Coordinate routine maintenance schedules and ensure instruments remain reliable and ready for high‑throughput use.
Monitor instrument performance, identify emerging issues, and implement improvements that support IPD research needs.
Support IPD researchers by ensuring equitable access to instrumentation and by maintaining clear documentation of instrument status and usage expectations.
Collaborate with IPD Lab Management to review emerging technologies and guide the adoption of new capabilities that strengthen IPD’s analytical and purification infrastructure.