Analytical Development Scientist

10x Genomics•Pleasanton, CA

About The Position

10x Genomics is seeking a highly skilled and motivated Analytical Development Scientist to join its Reagent and Analytical Development team. The role focuses on developing and implementing quality control assays and workflows for single cell and spatial biology products, with an emphasis on analytical chemistry. The scientist will work closely with domestic and international R&D and Manufacturing teams to help ensure product quality from concept through post-launch activities. The position leads the development, validation, and implementation of quality control methods and strategies across product platforms. It includes designing and improving end-to-end QC approaches, training QC colleagues, troubleshooting product and quality issues, investigating molecular interactions and failure modes, and communicating findings to cross-functional teams and leadership.

Requirements

PhD or MS in Molecular Biology, Biochemistry, Organic Chemistry, Analytical Chemistry, or a related field.
At least 2 years of relevant biotechnology or analytical chemistry industrial experience with a PhD, or at least 5 years with an MS.
Demonstrated experience designing, developing, and implementing QC strategies from raw materials to finished products.
Deep understanding and hands-on experience applying analytical chemistry and/or molecular biology techniques, including relevant methods for characterizing oligonucleotides, proteins, enzymes, antibodies, small molecules, and complex biological mixtures, as well as PCR and qPCR.
Demonstrated success developing, optimizing, and troubleshooting analytical chemistry assays.
Experience developing and implementing novel QC assays to assess performance using functional and orthogonal assays.
Demonstrated ability to document and transfer complex analytical assays into manufacturing and quality control environments.
Strong collaboration and communication skills across technical and non-technical parts of an organization.
Ability to manage multiple priorities and clearly communicate scientific results and recommendations.

Nice To Haves

Direct experience developing or working with single cell and/or spatial biology products.
Experience working in ISO 9001 or ISO 13485 environments.
Experience using statistical tools such as JMP or R to analyze complex data sets and create DOE experiments.
Experience automating analytical analyses and reports.
Previous experience supervising and/or mentoring junior staff.
Experience communicating and troubleshooting quality control issues with external suppliers.
Hands-on experience with 10x Genomics products.

Responsibilities

Lead and collaborate on the development, validation, and implementation of novel and orthogonal quality control methods for molecular biology products across single cell and spatial biology platforms.
Design, document, and implement efficient, cost-effective end-to-end QC strategies from raw materials through finished goods.
Optimize and continuously improve existing QC strategies and methods.
Train domestic and international QC team members on complex analytical assays, including reassessment and retraining for compliance as needed.
Independently troubleshoot and resolve issues related to product formulation, customer escalations, long-term storage, and quality control.
Design and conduct experiments to investigate molecular interactions in complex systems, including cause and effect, root causes of failure modes, manufacturing guardbanding, and optimization using DOE or other statistically driven approaches.
Document and update standard operating procedures (SOPs).
Present key findings to cross-functional teams and leadership.