Analytical Development Scientist (HPLC)

Thermo Fisher Scientific • Bedford, MA

1d • $92,000 - $135,000 • Onsite

About The Position

Thermo Fisher Scientific is seeking an innovative and highly motivated Analytical Development Scientist to join their R&D organization. This role will contribute to the development and commercialization of next-generation analytical technologies, with a primary focus on HPLC products and processes that support critical to quality attributes in the biotechnology and biopharmaceutical industries. The scientist will work in a collaborative, cross-functional environment to develop robust products, characterize product performance, and accelerate new product introductions that address critical customer needs. Experience or familiarity with analytical chromatography product development is highly desirable.

Requirements

• Ph.D. or M.S. with 3+ years of experience in Analytical Chemistry, Biochemistry, Chemical Engineering, Biotechnology, Pharmaceutical Sciences, or a related scientific field preferred; Bachelor's with 5+ years of experience in Analytical Chemistry, Biochemistry, Chemical Engineering, Biotechnology, Pharmaceutical Sciences, or a related scientific field acceptable.
• Hands-on experience with analytical chromatography systems, preferably HPLC or UHPLC.
• Strong understanding of analytical chromatography principles, method development, method optimization, and data interpretation.
• Experience developing or applying analytical methods used to characterize biological molecules, biopharmaceutical products, or process-related attributes.
• Experience designing experiments, analyzing analytical data, troubleshooting methods, and drawing technically sound conclusions.
• Demonstrated ability to work effectively in cross-functional technical teams.
• Strong technical writing, documentation, and communication skills.
• Scientific curiosity and a passion for innovation.
• Strong analytical, problem-solving, and critical-thinking skills.
• Ability to manage multiple priorities in a fast-paced R&D environment.
• Collaborative mindset with strong interpersonal skills.
• Attention to detail and commitment to high-quality experimental execution.
• Customer-focused approach to product and method development.
• Comfort working with ambiguity and translating technical data into practical recommendations.
• Continuous-improvement mindset and willingness to learn new technologies, applications, and workflows.
• Must be legally authorized to work in the United States without sponsorship.
• Must be able to pass a comprehensive background check, which includes a drug screening.

Nice To Haves

• Experience in a regulated, GMP-adjacent, quality-control, analytical development, process development, or biopharmaceutical laboratory environment.
• Familiarity with analytical methods used to monitor critical-to-quality attributes in biologics or bioprocessing workflows.
• Experience with one or more analytical characterization techniques such as SEC, ion exchange chromatography, reversed-phase chromatography, HIC, affinity chromatography, ELISA, IC, DLS, UV-Vis, CE, or mass spectrometry.
• Familiarity with analytical method lifecycle concepts, including method qualification, validation, transfer, robustness, precision, accuracy, specificity, and system suitability.
• Knowledge of FDA, ICH, USP, or other regulatory guidance related to drug quality, analytical methods, or biologics characterization.
• Experience with downstream purification, bioprocessing, biologics development, chromatography media, chromatography columns, or analytical workflow development.
• Experience supporting technical transfer, manufacturing validation, product launch, or customer-facing technical activities is a plus, but direct product development experience is not required.
• Ability to identify issues, troubleshoot experiments, adapt quickly based on data, and seek input when needed.

Responsibilities

• Develop, optimize, and apply analytical HPLC methods to characterize product performance and support new product development.
• Design and execute experiments to evaluate product attributes relevant to regulated bioprocessing, biologics development, and drug-quality monitoring.
• Develop analytical strategies to assess critical-to-quality attributes, including purity, aggregation, charge variants, identity, concentration, or other relevant product and process attributes.
• Generate, analyze, and interpret complex analytical datasets to guide technical decisions, product requirements, and development strategy.
• Evaluate HPLC product performance across relevant use conditions, sample types, workflows, and customer applications.
• Support product development activities, including feasibility studies, prototype evaluation, design verification, process optimization, technology transfer, and commercialization.
• Collaborate closely with Product Management, Applications, Manufacturing, Quality, Regulatory, Commercial, and other R&D teams throughout the product lifecycle.
• Support method transfer, manufacturing validation, and new product introduction activities through robust experimentation and clear documentation.
• Author technical reports, protocols, SOPs, test methods, presentations, and other scientific documentation.
• Identify technical risks, troubleshoot analytical challenges, and adapt experiments based on emerging data.
• Contribute to innovation initiatives by identifying new applications, technologies, customer needs, and product opportunities.
• Present technical findings and recommendations to internal stakeholders and, when appropriate, external customers.

Benefits

• Competitive remuneration
• Annual incentive plan bonus scheme
• Healthcare
• Company 401k
• A range of employee benefits
• A choice of national medical and dental plans, and a national vision plan, including health incentive programs
• Employee assistance and family support programs, including commuter benefits and tuition reimbursement
• At least 120 hours paid time off (PTO)
• 10 paid holidays annually
• Paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave)
• Accident and life insurance
• Short- and long-term disability in accordance with company policy
• Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
• Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount

What This Job Offers

• Job Type: Full-time
• Career Level: Senior