Analytical Chemistry Principal Research Associate

Vertex Pharmaceuticals•San Diego, CA

2d•Onsite

About The Position

Vertex is seeking an on-site Principal Research Associate, Analytical Chemistry to support medicinal chemistry programs through small molecule purification, analytical characterization, property assays and workflow optimization. This role will focus on HPLC and SFC purification, with a strong emphasis on SFC expertise, to help deliver high-quality compounds and data that enable rapid discovery efforts.

Requirements

Small molecule purification and characterization
Laboratory data systems and electronic lab notebooks
Familiarity with discovery informatics or compound tracking systems
Experience with software development, scripting, or coding
Ability to work effectively in cross-functional teams
Strong written and verbal communication skills
Demonstrated ability to work independently, manage priorities, and drive technical work with limited oversight
Strong hands-on experience with HPLC and/or SFC purification
Strong organizational, communication, and collaboration skills

Responsibilities

Purify small molecules using HPLC and SFC in support of medicinal chemistry programs.
Develop and optimize SFC purification methods, including chiral and achiral separations.
Perform analytical testing to confirm purity, identity, and quality of compounds.
Run small molecule property assays such as solubility, lipophilicity, and stability assessments.
Partner closely with medicinal chemists to support project timelines and compound delivery needs.
Troubleshoot purification and assay issues and help improve lab workflows.
Maintain accurate records and clearly communicate results to project teams.
Support routine operation and maintenance of chromatography instruments.