Analytical and Purification Senior Research Scientist

Vertex Inc.•Boston, MA

1d•Onsite

About The Position

We are seeking an Analytical and Purification Chemistry Senior Research Scientist to support discovery programs through the development and execution of analytical and purification strategies. This role requires deep expertise in separation science, with a particular focus on chiral purification using analytical and preparative supercritical fluid chromatography (SFC). The successful candidate will play a key role in delivering high-quality purified compounds and analytical data to cross-functional teams, enabling rapid progression of discovery programs. This position is intended for a scientist who can operate with a high degree of technical independence and serve as a subject matter expert in chiral purification and SFC-based separation science.

Requirements

Experience supporting medicinal chemistry or small-molecule drug discovery programs
Familiarity with a broad range of chiral stationary phases, mobile phase modifiers, and SFC screening strategies
Experience resolving complex stereochemical separations, including diastereomers and atropisomers
Experience with the analysis and purification of new modalities, including peptides, oligonulceotides, and lipids
Experience mentoring junior scientists or leading technical initiatives
PhD in Chemistry, Analytical Chemistry, or a related scientific discipline with 3–6 years of relevant industry experience; or MS in Chemistry, Analytical Chemistry, or a related scientific discipline with 8–10 years of relevant industry experience; or BS in Chemistry, Analytical Chemistry, or a related scientific discipline with 10–12 years of relevant industry experience

Responsibilities

Lead purification support for drug discovery programs using analytical/preparative HPLC and SFC
Develop, optimize, and troubleshoot chiral and achiral purification methods, with strong emphasis on enantioseparation using SFC
Design and execute screening strategies, including column selection and mobile phase optimization, to identify robust separation conditions
Evaluate crude reaction mixtures and determine fit-for-purpose purification strategies for complex compounds and stereoisomeric mixtures
Deliver purified compounds and analytical data to project teams in support of medicinal chemistry timelines and decision-making
Interpret analytical data related to compound identity, chemical purity, and chiral purity
Partner closely with medicinal chemists and cross-functional teams to address project needs
Serve as a technical expert in chiral chromatography and SFC-based purification workflows
Maintain, operate, and troubleshoot analytical and preparative purification instrumentation
Document experimental work, methods, and results clearly and accurately in appropriate laboratory systems
Contribute to continuous improvement of purification workflows, analytical methods, and laboratory operations
Mentor junior scientists and share technical expertise across the team