2027 Spring Intern - Purification, Microbiology, and Virology (PMV)

Genentech•Daly City, CA

3d•$30 - $47•Onsite

About The Position

The Purification, Microbiology, and Virology (PMV) department resides within Pharmaceutical Technical Development (PTD) and is responsible for developing, characterizing, validating and implementing recombinant protein and novel therapeutic purification processes, and implementing strict microbial and virus control for these processes, from laboratory to manufacturing scale. A PMV team member may be responsible for process development, commercial product support, continuous improvement activities, innovation projects, or other activities within the function. This internship position is located on-site in South San Francisco, California. This program provides a broad perspective and appreciation of the development of new processes, methods, and technologies at different production scales in the biotechnology industry. Candidates applying for the PMV Internship position should be passionate about science/engineering and thoroughly enjoy the challenges associated with complex problem-solving. Candidates must be highly self-motivated and able to work effectively as individuals and as part of multi-disciplinary teams in an atmosphere of casual intensity to develop medicines for unmet medical needs. Interns within PMV will work alongside scientists and engineers to design, execute, and analyze wet-lab, dry-lab, or digital-based experiments on the interface of process development and data science in support of the diverse development activities needed to produce therapeutics at scale for patients.

Requirements

Must be enrolled pursuing a Bachelor's degree at a minimum of sophomore standing.
Must have attained a Bachelor's Degree (not currently enrolled in a graduate program).
Must be pursuing a Master's Degree (enrolled student).
Must have attained a Master's Degree.
Must be pursuing a PhD (enrolled student).
Must have attained a PhD.
Chemical Engineering, Biomedical Engineering, Mechanical Engineering, Bioengineering, Pharmaceutical Engineering, Chemistry, Biology, Microbiology, Biophysics, Computer Science & Engineering, or related disciplines.
Detail-oriented, enthusiastic, and self-motivated individual excited about tackling complex scientific challenges in an industrial setting.
Excellent written and verbal communication, collaboration, and interpersonal skills.
Complements our corporate culture and values: Integrity, Courage, and Passion.
High degree of adaptability and ability to exercise independent judgment to solve problems creatively.
Relevant work experience in research labs or the biotechnology industry.
Knowledge of large-scale biopharmaceutical manufacturing and purification processes (harvest, chromatography, filtration, UF/DF), including scale-up/scale-down, biochemical engineering principles, and data analysis.
Familiarity with other departments within the biopharmaceutical industry (cell culture, analytics, quality control, MSAT, etc.)
Understanding of cGMP/GLP requirements and exposure to statistical/multivariate data analysis techniques.
Proven ability to work both independently and collaboratively in multi-disciplinary or cross-functional teams to implement technical changes and process improvements.

Nice To Haves

Experience working with proteins.
AKTA Avant Chromatography (column packing, Affinity, IEX, HIC, &/or Multimodal chromatography).
pH / conductivity, buffer preparation, pipetting.
Technical communication (ELN, report writing, presentations).
HPLC-SEC.
UV-Vis.
Lab Automation (Robotic Liquid Handlers, batch binding screens, robocolumns).
Normal Flow Filtration (constant flux, constant pressure, viral filtration, depth filtration).
Tangential Flow Filtration (TFF) or Ultrafiltration Diafiltration (UF/DF).

Responsibilities

Design, execute, and analyze wet-lab, dry-lab, or digital-based experiments on the interface of process development and data science in support of the diverse development activities needed to produce therapeutics at scale for patients.
Innovative downstream processing approaches aimed at boosting efficiency, adaptability, and cost savings
Evaluation of novel raw materials or processing steps to improve productivity and sustainability
Development of new clearance strategies and/or steps for adventitious agents and viruses
Protein structure and stability studies to inform process robustness
Purification strategies for problematic impurities or species
High throughput assay workflow development to assess purification and bioconjugate process development
Optimization and automation of data analysis using AI platforms