Clinical Trial Manager Jobs

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Senior Clinical Trial Manager - Internal Medicine (U.S.)

Worldwide Clinical Trials•Carolina, NC
•Remote

About The Position

Worldwide Clinical Trials is hiring a Senior Clinical Trial Manager to lead clinical site management activities and support the successful execution of clinical trials from study start-up through closeout. The role provides strategic and operational leadership for clinical monitoring and site activities, working closely with sponsors, Clinical Research Associates (CRAs), and cross-functional project teams to deliver quality, efficiency, and high-quality outcomes. This is a remote role for candidates based in the United States, collaborating with global teams across multiple time zones. Travel of up to 25% is required to support study and site management activities. The position requires a bachelor's or nursing degree, experience in clinical trial leadership and as a CRA, experience supporting Internal Medicine clinical trials, and the ability to lead and support remote teams.

Requirements

  • Bachelor’s degree or nursing degree.
  • At least 2 years of experience as a Clinical Trial Manager, Clinical Operations Leader, Clinical Trial Lead, or in an equivalent role.
  • At least 4 years of experience as a Clinical Research Associate.
  • Ability to travel up to 25%; a valid passport is required.
  • Experience supporting Internal Medicine clinical trials, including IMID, Cardio Metabolic, or Rare Disease trials.
  • Demonstrated ability to lead, motivate, and support remote teams.

Responsibilities

  • Lead and provide direction to Clinical Research Associates and site management team members throughout the full study lifecycle.
  • Serve as the primary Site Management representative for clinical monitoring and site activities across assigned projects.
  • Act as a key sponsor-facing contact, building partnerships and ensuring effective communication throughout study execution.
  • Oversee monitoring deliverables to support study objectives, quality expectations, and budget requirements.
  • Identify and manage out-of-scope activities, proactively communicating potential impacts and solutions.
  • Drive collaboration across cross-functional teams to ensure consistent execution of clinical site management activities.
  • Support high-quality study conduct by providing leadership, guidance, and operational oversight to project teams.

Benefits

  • Competitive benefits package, depending on location.

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Based on current job postings on Teal, the average Clinical Trial Manager salary in the US is approximately $148,000 per year, with a typical range of $70,000 to $218,000.
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