(Sr.) Manager, Clinical Supply Chain
About The Position
Centessa Pharmaceuticals plc (Nasdaq: CNTA) new kind of pharmaceutical company with a deconstructed R&D environment that prioritizes data driven decision making led by subject matter experts. Centessa is advancing a portfolio of high conviction programs with strong biological validation. Our asset-centric model offers a unique R&D logic that has been applied by single asset companies to improve productivity. This operating model has minimal centralized infrastructure, reduced hierarchy, and exclusive focus on data driven capital allocation. Our teams are uniquely incentivized to expeditiously interrogate key scientific hypotheses. We believe the asset-centric model can lead to improved success rates for programs with greater speed and modest costs. Description of Role Centessa is seeking a (Sr.) Manager, Clinical Supply Chain to oversee end-to-end planning, execution, and maintenance of uninterrupted clinical supply, including IP, comparators, and ancillary materials. This role ensures compliance with GxP requirements, study timelines, and budgets while partnering cross functionally with Clinical Operations, CMC, Quality, Regulatory, Finance, and external vendors. Reporting to the Senior Director, Clinical Supply Chain, the individual will build strong relationships with internal teams and third-party suppliers to align objectives and ensure successful trial execution. Key responsibilities include managing clinical forecasts, inventory systems, and IRT tools with strong attention to detail and daily operational oversight.
Requirements
- Bachelor’s degree in engineering or science is required.
- 5-8 years of biotech/pharma industry experience in clinical supply with international experience is required
- Experience in all aspects of clinical supply chain as well as a deep understanding of GMP/GDP
- Requires a strong understanding of managing groups, CMOs and CDMOs
- Proven background in working with small molecule modality required
- Strong organizational, analytical, decision-making and interpersonal skills
- Ability to work independently in a fast-paced dynamic environment
- Demonstrated ability to coordinate CDMO activities in the development and commercialization of pharmaceutical products
- Excellent organizational skills, project management skills and detail-orientated leadership approach
- Ability to thrive in a small company culture and assist in creating and implementing processes.
Nice To Haves
- Experience with blistering and walleting packaging processes preferred
- Experience operating within a commercial drug product environment preferred
Responsibilities
- Lead development and execution of clinical supply strategies for early- to mid-phase clinical trials (Phase 1–3 as applicable).
- Own clinical supply plans, demand forecasts, and inventory strategies aligned with protocol requirements and enrollment projections.
- Manage packaging, labeling, distribution, and resupply activities for investigational products and comparators.
- Ensure on-time delivery of clinical supplies to depots and clinical sites globally.
- Collaborate with Quality, Clinical, CMC and external CDMOs to develop and approve clinical labels.
- Manage CDMO packaging/labeling schedules to ensure availability of clinical supplies.
- Interact regularly with third-party providers to manage logistics & licenses required to ship materials from manufacturing to bulk storage facilities, courier depots and investigator sites.
- Work with CMC and QA to facilitate document transfer required for CTM/QP release by CDMOs
- Manage and track clinical supply inventory either manually or through an Interactive Response Technology (IRT) system.
- Manage Product Recovery pending investigation of CTM from investigator sites as needed.
- Effectively collaborate and communicate across multiple functional areas, bringing a sufficient breadth of knowledge.
- Monitor shelf-life and expiry dating and coordinate retest extension with analytical team to ensure continuous supply.
- Manage investigation, reporting and communication of outcomes from temperature excursions and product complaints.
- Author Pharmacy Manuals for clinical studies, as needed
- Represent Supply Chain in Clinical and CMC Sub Team meetings
Benefits
- In addition to base pay, this role is eligible for a discretionary annual bonus and participation in our equity program, allowing you to share in Centessa’s long-term success.
- Centessa also offers a comprehensive benefits package, which includes a 401(k) plan, company-sponsored medical, dental, vision, and life insurance, generous paid time off, and a health and wellness program.
Stand Out From the Crowd
Upload your resume and get instant feedback on how well it matches this job.
What This Job Offers
Job Type
Full-time
Career Level
Manager
