Sr. Director Evidence Generation

BridgeBio Pharma•San Francisco, CA

5h•Hybrid

About The Position

In 2015, we pioneered a “moneyball for biotech” approach, pooling projects and promising early-stage research from academia together under one financial umbrella to reduce risk and unleash innovation. This model allows science and small teams of experts to lead the way. We build bridges to groundbreaking advancements in rare disease, and develop life-changing medicines for patients with unmet needs as fast as humanly possible. Together we define white space, push boundaries and empower people to solve problems. If you're someone who defies convention, join us and work alongside some of the most respected minds in the industry. Together, we'll ask "why not?" and help reengineer the future of biopharma. What You’ll Do The Senior Director, Evidence Generation, Skeletal Dysplasia is a senior medical leadership role within Medical Affairs, responsible for developing and executing the integrated evidence generation strategy across BridgeBio’s skeletal dysplasia programs. Reporting to the CMAO, Skeletal and Endocrinology, this role will lead the design and implementation of real-world evidence (RWE), HEOR, Phase 4, registry, and investigator-sponsored research strategies to support clinical development, regulatory objectives, value demonstration, and lifecycle management. This leader will play a critical role in shaping the evidence strategy to support launch readiness and post-marketing commitments, while ensuring alignment across Clinical Development, Regulatory, Commercial, Market Access, and Field Medical. The role requires deep expertise in rare disease evidence generation, scientific rigor, and cross-functional leadership in a matrixed organization.

Requirements

MD, DO, PharmD, PhD, or equivalent advanced scientific or clinical degree
10+ years of experience in Medical Affairs, Clinical Development, HEOR, or Evidence Generation roles within the biopharmaceutical industry and/or academic medicine
Demonstrated experience leading integrated evidence generation strategy in rare disease strongly preferred
Experience in skeletal disorders, endocrinology, rare genetic diseases, or metabolic bone disease preferred
Proven expertise in real-world evidence (RWE), registries, HEOR, and Phase 4 study design and execution
Experience supporting late-stage development, launch preparation, and post-marketing medical activities
Strong understanding of regulatory and compliance requirements related to medical research and post-marketing studies
Demonstrated ability to lead cross-functional teams in a matrixed, fast-paced environment
Strategic thinker with strong execution capabilities
Excellent written and verbal communication skills, including experience presenting to senior leadership and external stakeholders
High degree of scientific rigor, integrity, and patient-centered focus
Ability to travel up to ~30–40% domestically and internationally for scientific meetings, advisory boards, investigator meetings, and internal engagements; occasional evening and weekend work may be required based on business needs.

Nice To Haves

Demonstrated experience leading integrated evidence generation strategy in rare disease strongly preferred
Experience in skeletal disorders, endocrinology, rare genetic diseases, or metabolic bone disease preferred

Responsibilities

Lead the development and execution of the integrated evidence generation strategy for skeletal dysplasia programs, aligned with overarching medical and asset strategy
Design and oversee real-world evidence (RWE) initiatives, including registries, natural history studies, external data collaborations, and database analyses
Partner with HEOR to generate data supporting value demonstration, payer engagement, and health technology assessment (HTA) requirements
Lead Phase 4 planning and execution, including post-marketing commitments and lifecycle management studies
Develop and manage investigator-initiated study (IIS) strategy and governance to address key scientific gaps
Partner with Clinical Development to ensure evidence generation plans are integrated across development phases and support regulatory interactions
Collaborate with Regulatory, Commercial, Market Access, and Patient Advocacy to ensure evidence plans address stakeholder needs
Establish and maintain relationships with key opinion leaders (KOLs), academic investigators, and patient organizations within skeletal dysplasia and related specialties
Represent BridgeBio at scientific congresses, advisory boards, and external forums
Oversee evidence dissemination strategy in partnership with Scientific Communications, including publications and congress presentations
Serve as medical reviewer and approver for relevant medical and cross-functional materials to ensure scientific accuracy and compliance
Contribute to internal medical education and onboarding initiatives

Benefits

Market leading compensation
401K with 100% employer match on first 3% & 50% on the next 2%
Employee stock purchase program
Pre-tax commuter benefits
Referral program with $2,500 award for hired referrals
Comprehensive health care with 100% premiums covered - no cost to you and dependents
Mental health support via Spring Health (6 therapy sessions & 6 coaching sessions)
Hybrid work model - employees have the autonomy in where and how they do their work
Unlimited flexible paid time off - take the time that you need
Paid parental leave - 4 months for birthing parents & 2 months for non-birthing parents
Flex spending accounts & company-provided group term life & disability
Subsidized lunch via Forkable on days worked from our office
People are part of our growth and success story - from discovery to active drug trials and FDA pipelines, there are endless opportunities for skill development and internal mobility
We provide career pathing through regular feedback, continuous education and professional development programs via LinkedIn Learning, LifeLabs, Spring Health & BetterUp Coaching
We celebrate strong performance with financial rewards, peer-to-peer recognition, and growth opportunities