Senior Scientist, Translational Science & Diagnostics (TSDx)

Bicycle Therapeutics•Lexington, MA

1d•$126,000 - $157,000

About The Position

Your mission is to apply your scientific expertise to the design, execution and analyses of translational data packages derived for assets in our clinical oncology portfolio. Working as a key member of cross-functional teams, you will be responsible for developing and analyzing biomarker assay data from multiple modalities (IHC, NGS, FISH, imaging etc.) and contributing directly to the advancement of our novel Bicycle Drug Conjugates (BDCs) and Bicycle Radio Conjugates (BRCs) from discovery into the clinic, including companion diagnostics development.

Requirements

Demonstrated expertise in a biopharmaceutical setting of design, delivery, analysis and interpretation of clinical biomarker data (e.g. IHC, NGS, FISH, imaging etc.), in oncology clinical trials (solid or liquid tumors).
Demonstrated capability of delivering clinical biomarker assay development at third party laboratories within the context of a clinical trial. Experience working as biomarker lead within global oncology project teams is highly desirable.
Familiarity with and experience of the regulatory requirements of conducting clinical biomarker studies, up to and including companion diagnostics would be an advantage.
Advanced degree (MS, PhD, or equivalent) in a relevant scientific discipline is preferred

Responsibilities

Contribute to the design and execution of translational strategies that align with project goals, focusing on the development of robust biomarker packages for patient selection, proof-of-mechanism, and pharmacodynamic assessment.
Represent TSDx department on global project teams for nuzefatide pevedotin (BT5528) and zelenectide pevedotin (BT8009) to execute prioritized team biomarker strategy.
Identify and champion opportunities for innovation across biomarker analytical methodologies proposing creative solutions and new approaches to solve scientific challenges.
Independently perform and oversee quantitative analysis of biomarker data sets from clinical studies, through management of activities at third party laboratories (e.g. CROs and/or academic collaborators), to ensure delivery of high-quality, timely, interpretable results.
Lead authorship of biomarker sections of team technical documents, such as clinical protocols, investigator brochure, lab manual, and regulatory briefing books as required. Seek opportunities to contribute to present clinical biomarker data packages via external scientific publications.
Present scientific findings and their interpretation clearly and effectively at project team meetings and to cross-functional stakeholders.

Benefits

Flexible working environment
Competitive reward including annual company bonus
Medical, dental, and vision insurance for eligible employees and their families with 100% of the premiums covered by the Company
Health and Dependent Care Flexible Spending Accounts
401(k) plan with a 4% Company match and immediate vesting
Eligibility to accrue up to 23 paid time off days per full year worked, plus the option to buy up to 5 additional days
Employee assistance program
Employee recognition schemes
10 Company holidays
Competitive Family Leave Policy
Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.