Scientist, Translational Pathology

Bristol Myers Squibb • Needham, MA

1d • Onsite

About The Position

The successful scientist will work with colleagues throughout BMS to establish assays using immunohistochemistry, multiplex staining/imaging, in situ nucleic acid hybridization, and digital pathology. The scientist will be directly responsible for the design, development, execution, and analysis of translational tissue-based biomarker assays to interrogate target prevalence, target engagement, mechanisms of action, pharmacokinetics, pharmacodynamics, and prediction of treatment response. The position entails working on projects independently and in multi-disciplinary teams consisting of pathologists, lab scientists, data scientists and clinical biomarker scientists. The IHC scientist will develop tissue-based assays for internal or external use with accountability for assays transferred to partner labs and contract research organizations (CROs). The scientist will also be responsible for working with digital pathology colleagues to build and assess image analysis algorithms and workflows.

Requirements

• Bachelor’s degree in biological sciences or related field with minimum 4+ years industry experience
• Experience in monoplex and multiplex IHC assay development (chromogenic and fluorescence) with comprehension of the underlying principles
• Experience with automated IHC platforms
• Working knowledge of histology/morphology/pathology interpretation relevant to assay development
• Ability to evaluate and onboard new technologies related to tissue-based biomarker development
• The ability to thrive and self-motivate in an interdisciplinary workplace
• The ability to clearly communicate (verbal and written) scientific objectives, logical experimental design and the analysis and interpretation of data
• Experience with formalin-fixed paraffin-embedded workflows
• Experience with in-situ nucleic acid hybridization (RNA/DNA) studies on slide-based tissue samples
• Experience with digital scanning, image management systems (IMS), and digital image analysis platforms (HALO, Visiopharm) for H&E, immunohistochemical and multiplexed fluorescence images.

Nice To Haves

• Prior experience with early discovery programs and exploratory assay development
• Prior experience working in the fields of oncology and immuno-oncology
• Prior experience working in a regulated laboratory setting (CAP/CLIA or other GxP environment) is a plus but not necessary
• Experience with data analysis tools in R and/or Python

Responsibilities

• Responsibility for all aspects of assay development including intake, research, planning, development, coordination, execution, risk communication/management, updates and transfer of assays including (but not limited to) chromogenic immunohistochemistry (IHC), in-situ nucleic acid hybridization, multiplexed immunofluorescence (mIF) and digital pathology
• Design, organization, and execution of assay development workflow strategies (feasibility, verification, and validation), with appropriate knowledge and use of controls and test tissues
• Maintain technical proficiency across several IHC, mIF, histology and digital scanner technologies
• Coordinate with pharmacology teams to advise on preclinical models and study design parameters
• Responsible for working on multiple development projects simultaneously with appropriate project prioritization while also participating in lab management and other lab initiatives
• Review and scoring of stained slides with the engagement of pathologist oversight and review as needed
• Maintain workplace and lab compliant processes, documentation, and communication

Benefits

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Number of Employees: 5,001-10,000 employees