Senior Scientist, Translational Neuroscience
About The Position
We are seeking a highly skilled in vivo scientist to significantly advance neurodegenerative disease research, with a focus on Parkinson's disease. The individual will be instrumental in designing, executing, and interpreting experiments using rodent models to investigate neurological and aging disorders and evaluate therapeutic interventions. This will enhance the Translational Neuroscience team's in vivo research capacity, establish advanced models for due diligence, and test novel drug mechanisms of action. The scientist will also be crucial in modeling novel aspects of neurodegenerative diseases, incorporating human cohort findings, and setting up mechanistic models to test hypotheses from new target discovery.
Requirements
- Ph.D. in Neuroscience, Biology, Pharmacology, or a related field, with 5+ years relevant postdoctoral or equivalent industrial experience
- Experience in live animal surgeries
- Extensive experience with broad animal behavioral assessment techniques
- Expertise in rodent handling, compound treatments, micro sampling, and CNS tissue harvests
- Experience in longitudinal monitoring of behavior and colony maintenance
- Practical experience in cellular assays
- Skilled in cells and tissue immunohistochemistry and microscopy, including basic histological techniques for tissue processing, staining, and image analysis
- Excellent communication, interpersonal, and organizational skills
- Ability to work independently and collaboratively within multidisciplinary team
- Meticulous with attention to detail
- Must be willing to work onsite 5 days a week
Responsibilities
- Develop and characterize novel in vivo models of neurodegeneration and age-related biology
- Design and execute in vivo functional experiments for target validation and mechanistic biology studies
- Conduct broad animal behavioral assessments to characterize neurological phenotypes
- Analyze, interpret, and communicate data and results effectively to the team
- Document data and protocols in accordance with Calico guidelines, maintaining meticulous records of experiments, data, and findings
- Contribute to experimental design, data interpretation, and presentation of results
- Collaborate effectively across multiple functional teams
- Adhere to all animal welfare regulations and institutional guidelines
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Ph.D. or professional degree
