Senior Scientist, QSP Modeling

Simulations Plus

1d•Remote

About The Position

Simulations Plus stands as a premier provider in the biopharma sector, offering advanced software and consulting services that enhance drug discovery, development, research, clinical trial operations, regulatory submissions, and commercialization. Our comprehensive biosimulation solutions integrate artificial intelligence/machine learning, physiologically based pharmacokinetics, physiologically based biopharmaceutics, quantitative systems pharmacology/toxicology, and population PK/PD modeling approaches. We also deliver simulation-enabled performance and intelligence solutions alongside medical communications support for clinical and commercial drug development. Our cutting-edge technology is licensed and utilized by leading pharmaceutical, biotechnology, and regulatory agencies worldwide. Leadership truly cares about maintaining a positive culture and employee well-being. We offer fully remote work, flexible schedules, and generous vacation policy along with affordable health coverage, stock options, annual bonuses, and more! The Senior Scientist will lead the mathematical representation of core areas within the DILIsym Services areas of expertise, some core areas include mitochondrial dysfunction, bile acid transport, immune response/cell death, biomarkers, pharmacokinetics, lipotoxicity, NAFLD and NASH, IPF, and kidney injury.

Requirements

10+ years of QSP/QST modeling experience
General knowledge of pharmacology, biology, biochemistry, lipid biochemistry, immunology, and/or toxicology
Proficiency in SimBiology, MATLAB, Python, or R
PK modeling, PKPD modeling, and systems pharmacology modeling
Proficiency in mathematics
Understand development process and how to apply modeling and simulation for maximum impact
Strong critical thinking and problem solving skills
Strong verbal and written communication skills
Maintain a positive attitude while interacting with colleagues and clients
Must be able to multitask and have great organizational skills
Self-motivated with ability to work with minimal supervision
Minimal travel required up to 10%

Nice To Haves

Experience with GastroPlus™ or DILIsym preferred
PhD in pharmaceutical science, biomedical engineering, or related life sciences field preferred

Responsibilities

Design, write, test, and use computer code to build and maintain the sub-model(s) related to a given core area (e.g. DILIsym, NAFLDsym, IPFsym, RENAsym, RADAsym)
Represent compounds and drugs in DILIsym, including translating laboratory data into model parameters
Contribute to the activities required for successful completion of all goals, including those of the various development efforts and the DILI-sim Initiative consortium
Combine technical and project management work, including components such as systems pharmacology modeling, software code development, and maintenance in MATLAB or other designated software environments
Develop plans to complete all tasks and provide all deliverables within a time frame consistent with the services agreement signed with the sponsor
Schedule the necessary meetings including internal and external collaborators
Travel to sponsor locations to participate in key milestone meetings as required
Exerts leadership in the area of report and presentation preparation, which are critical final deliverables for all projects
Manage and participate in preparation and review of all joint manuscripts between the DILIsym Services and the sponsor
Ensure the effort expended for a given project remains consistent with the resources allocated for the project per the signed contract
Publish work in scientific journals, with minimal review required by their supervisor, including documentation preparation, text development, figure development, and correspondence with editors and peer reviewers
Oversee and supervise the technical work of others and mentor less experienced scientists
Train others on QSP/QST and the various DSS platforms
Other duties as assigned