Senior Scientist: Medicinal Chemistry

Biogen•Cambridge, MA

1d•$124,000 - $166,000

About The Position

About This Role Biogen has made a substantial investment in a state-of-the-art parallel medicinal chemistry (PMC) suite, and we are looking for a creative, talented scientist to apply cutting-edge approaches to discover new medicines to treat CNS and immunological disorders. The successful candidate will hold a key role in the Medicinal Chemistry group working closely together with project teams to identify opportunities for library synthesis. The candidate will drive the strategy for internal and external PMC efforts to support programs from the Hit ID to Lead Optimization phase of discovery. This important position is embedded in the Chemical Technologies group and together with H.T.E. experts the PMC scientist will enable and implement diverse and robust approaches to PMC synthetic routes. In addition, as a key contributor to small molecule discovery projects, the candidate will need to demonstrate independent problem-solving skills and work well in a team environment. What You’ll Do Collaborate regularly with medicinal chemistry teams on designing, prioritizing, and executing focused libraries that help the team address critical issues Drive the internal and external PMC strategy and manage the seamless access to building block resources Develop new synthetic routes to enable diverse and robust parallel medicinal chemistries Partner with the High Throughput Experimentation (H.T.E.) team to identify optimal reaction conditions. Perform manually and/or automated parallel synthesis and work-up procedures of focused libraries on small scale Maintain a significant laboratory presence that is focused on identifying and enabling critical synthetic chemistry for advancing the projects as well for use by chemistry CROs Manage and oversee work done by CROs Who You Are You are a scientist with a strong background in medicinal/synthetic organic chemistry, capable of running reactions in parallel, and eager to explore new chemistry transformations and turn them into robust library formats. You love learning new technological skills and you are interested in improving process efficiencies. You are self-driven, well organized and a team player who can work across multiple programs to make impactful contributions to drug discovery.

Requirements

Ph.D. in organic or medicinal chemistry with minimum of 3 years biopharmaceutical medicinal chemistry experience or M.S. with a minimum of 5 years biopharmaceutical medicinal chemistry experience
Strong commitment to experimental research, in particular the application of synthetic organic chemistry for drug discovery
Demonstrated ability to apply cutting-edge chemistry to identify flexible synthetic routes to introduce multiple points of diversification
A proven track record of high productivity in a medicinal chemistry lab preparing analogs of hits and leads
Experienced in the use of analytical methods for the characterization of organic compounds
A strong desire for continuous learning and professional growth
Excellent multi-tasking skills and ability to keep track of progress on multiple projects
Excellent communication skills and fluency in lab science
Strict adherence to standard lab procedures and safety practices
A team player who works effectively within a diverse team of co-workers and across disciplines

Nice To Haves

Previous experience in parallel synthesis, design of experiments, automation, reaction optimization or other technologies in the context of organic synthesis is highly desirable.
Previous experience in direct-to-biology and mixture-based library synthesis and screening preferable.

Responsibilities

Collaborate regularly with medicinal chemistry teams on designing, prioritizing, and executing focused libraries that help the team address critical issues
Drive the internal and external PMC strategy and manage the seamless access to building block resources
Develop new synthetic routes to enable diverse and robust parallel medicinal chemistries
Partner with the High Throughput Experimentation (H.T.E.) team to identify optimal reaction conditions.
Perform manually and/or automated parallel synthesis and work-up procedures of focused libraries on small scale
Maintain a significant laboratory presence that is focused on identifying and enabling critical synthetic chemistry for advancing the projects as well for use by chemistry CROs
Manage and oversee work done by CROs

Benefits

Medical, Dental, Vision, & Life insurances
Fitness & Wellness programs including a fitness reimbursement
Short- and Long-Term Disability insurance
A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
Up to 12 company paid holidays + 3 paid days off for Personal Significance
80 hours of sick time per calendar year
Paid Maternity and Parental Leave benefit
401(k) program participation with company matched contributions
Employee stock purchase plan
Tuition reimbursement of up to $10,000 per calendar year
Employee Resource Groups participation