Associate Principal Scientist, Medicinal Chemistry

Neomorph•San Diego, CA

17d

About The Position

We are seeking a highly motivated medicinal chemist with excellent leadership skills, strong in strategic thinking and experienced with working in multi-disciplinary teams (spanning chemistry, biology, analytical sciences, pharmacology, DMPK and toxicology). The successful candidate will lead projects from inception to clinical candidate nomination, advancing our targeted protein degradation (TPD) platform. Applicants should be experienced drug hunters with a track record of innovation and creative problem solving. The candidate will also manage collaborations and CRO resources as needed.

Requirements

Ph.D. in organic chemistry with 6+ years, MS with 9+ years or BS with 12+ years of relevant experience
High level of creativity and productivity with strong synthetic problem-solving skills, synthetic methods and reactions mechanisms are required
Demonstrate expertise in drug design and medicinal chemistry strategies to improve drug-likeness, ADME/DMPK and safety properties
The candidate should have experience in both structure based and ligand based drug design concepts
The candidate should have experience working with external drug discovery CROs
The candidate should have deep understanding of molecular properties and DMPK concepts
Knowledge and experience in assessing and establishing intellectual property
The candidate should have an established interest and passion for new modalities and targeted protein degradation
Exceptional interpersonal skills

Nice To Haves

Experience in targeted protein degradation as a therapeutic modality.

Responsibilities

Responsible for the success of chemistry aspects of a drug discovery team through individual contributions, and through mentorship of junior colleagues [DP1]
Can independently lead a Lead Optimization project and manage the chemistry team to advance towards candidate selection in collaboration with other line functions
Leading from the bench- candidate will spend a portion of their time in the lab, enabling and impacting from the bench
Accountable for providing guidance, direction and contributing to project delivery through the development of people
Manage external chemistry CROs and work with external partners to profile compounds
Work within mandated laboratory safety policies and practices and maintain an electronic notebook to company standards
Contribute to patent filings, publications and presentations

Benefits

Industry competitive compensation
Annual target bonus
Stock options
401K plan
Career advancement opportunities
Monthly town halls to share business and scientific updates
Work Hard, Stay Well
Comprehensive medical, dental, and vision plans for employees and their dependents
Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution
Employee Assistance Program
10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave.
Supplemental pay for Pregnancy Disability Leave
Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care
Lifestyle
Casual work environment
Volunteer days off each year to spend time contributing to causes you care about
Flexible work schedule
Access to onsite gym
Onsite space to store your bicycle (or surfboard)
Have Fun!
We believe in work/life balance and Fun is at the core of our Core Values. In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day).