Senior Scientist - Medicinal Chemistry

The businesses of Merck KGaA, Darmstadt, Germany•Billerica, MA

12d

About The Position

Work Your Magic with us! Start your next chapter and join EMD Serono. Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us. United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe. This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US. Your Role: EMD Serono in Billerica, MA is seeking a Senior Scientist – Medicinal Chemistry to add to their Oligonucleotide Therapeutics Group (DDTech).

Requirements

PhD in Medicinal Chemistry, Synthetic Organic Chemistry, Chemical Biology, or other Science field with 5+ years of industry experience
Strong technical background in nucleoside chemistry, Peptides and small molecules
Strong track record of laboratory-based innovation and problem-solving in drug discovery including optimization of affinity, selectivity, drug properties, and PK profile
Proven expertise in hands-on peptide synthesis
Expertise in analytical characterization (e.g. SEC-HPLC, NMR, IEX, IPRP, LC-MS)
Excellent communication skills for both technical and non-technical audiences
Exceptional communication skills with the ability to translate complex data into internally as well as with CRO’s

Responsibilities

Implement modern peptide chemistry and conjugation methodologies to accelerate optimization of miniprotein drug development
Design and execute receptor expression profiling, ligand–receptor binding, internalization, and trafficking assays
Collaborate with cross-functional teams including computational chemistry, biology, and pharmacology to drive project success
Method Development & Analytics: Establish high-resolution analytical methods and pipelines. You will be directly responsible for developing and proceduralizing in-process testing and finished product QC using HPLC (SEC, IEX, IPRP) and LC-MS.
Innovation: drive innovation to improve circulating half-life, tissue penetration, cellular uptake, and intracellular bioavailability of payloads